Assessment of Structural Intolerance and Durability
General Structure Information 4dlo BAI3 crystal structure of the gain and hormr domains of brain angiogenesis inhibitor 3 (bai3) 2.3Å AUTH D.ARAC,A.A.BOUCARD,M.F.BOLLIGER,J.NGUYEN,S.M.SOLTIS,AUTH 2 T.C.SUDHOF,A.T.BRUNGERTITL A NOVEL EVOLUTIONARILY CONSERVED DOMAIN OF CELL-ADHESIONTITL 2 GPCRS MEDIATES AUTOPROTEOLYSIS.REF EMBO J. V. 31 1364 2012REFN ISSN 0261-4189PMID 22333914DOI 10.1038/EMBOJ.2012.26 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1fyx TLR2 crystal structure of p681h mutant of tir domain of human tlr2 2.8Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d9w DOK2 solution structure of the ph domain of docking protein 2 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF DOCKINGTITL 2 PROTEIN 2 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2d9z PRKD3 solution structure of the ph domain of protein kinase c, nu type from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, NU TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2iwq MPDZ 7th pdz domain of multiple pdz domain protein mpdz 1.8Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2hz6 ERN1 the crystal structure of human ire1-alpha luminal domain 3.1Å AUTH J.ZHOU,C.Y.LIU,S.H.BACK,R.L.CLARK,D.PEISACH,Z.XU,AUTH 2 R.J.KAUFMANTITL THE CRYSTAL STRUCTURE OF HUMAN IRE1 LUMINAL DOMAINTITL 2 REVEALS A CONSERVED DIMERIZATION INTERFACETITL 3 REQUIRED FOR ACTIVATION OF THE UNFOLDED PROTEINTITL 4 RESPONSE.REF PROC.NATL.ACAD.SCI.USA V. 103 14343 2006REFN ISSN 0027-8424PMID 16973740DOI 10.1073/PNAS.0606480103 Variant Set Distributions Mapped […]
General Structure Information 3rru TOM1L1 x-ray crystal structure of the vhs domain of human tom1-like protein, northeast structural genomics consortium target hr3050e 3.0Å AUTH F.FOROUHAR,S.LEW,J.SEETHARAMAN,H.WANG,C.CICCOSANTI,D.PATEL,AUTH 2 T.B.ACTON,R.XIAO,J.K.EVERETT,G.T.MONTELIONE,J.F.HUNT,L.TONGTITL X-RAY CRYSTAL STRUCTURE OF THE VHS DOMAIN OF HUMAN TOM1-LIKETITL 2 PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGETTITL 3 HR3050EREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nzj REM1 the crystal structure of rem1 in complex with gdp 2.5Å AUTH A.P.TURNBULL,E.PAPAGRIGORIOU,E.UGOCHUKWU,J.M.ELKINS,AUTH 2 M.SOUNDARARAJAN,X.YANG,F.GORREC,C.UMEANO,E.SALAH,N.BURGESS,AUTH 3 C.JOHANSSON,G.BERRIDGE,O.GILEADI,J.BRAY,B.MARSDEN,S.WATTS,AUTH 4 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,M.SUNDSTROM,AUTH 5 D.DOYLETITL THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bh7 RP2 crystal structure of the rp2-arl3 complex bound to gdp-alf4 1.9Å AUTH S.VELTEL,R.GASPER,E.EISENACHER,A.WITTINGHOFERTITL THE RETINITIS PIGMENTOSA 2 GENE PRODUCT IS ATITL 2 GTPASE-ACTIVATING PROTEIN FOR ARF-LIKE 3REF NAT.STRUCT.MOL.BIOL. V. 15 373 2008REFN ISSN 1545-9993PMID 18376416DOI 10.1038/NSMB.1396 Variant Set Distributions Mapped Variants
General Structure Information 2ct3 SORBS3 solution structure of the sh3 domain of the vinexin protein -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THETITL 2 VINEXIN PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants