Assessment of Structural Intolerance and Durability
General Structure Information 2kl7 EFEMP2 solution nmr structure of the egf-like 1 domain of human fibulin-4. northeast structural genomics target hr6275 -1.0Å AUTH P.ROSSI,Y.CHIANG,S.ANDERSON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE EGF-LIKE 1 DOMAIN OFTITL 2 HUMAN FIBULIN-4. NORTHEAST STRUCTURAL GENOMICSTITL 3 TARGET HR6275REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m20 EGFR egfr transmembrane – juxtamembrane (tm-jm) segment in bicelles: md guided nmr refined structure. -1.0Å AUTH N.F.ENDRES,R.DAS,A.W.SMITH,A.ARKHIPOV,E.KOVACS,Y.HUANG,AUTH 2 J.G.PELTON,Y.SHAN,D.E.SHAW,D.E.WEMMER,J.T.GROVES,J.KURIYANTITL CONFORMATIONAL COUPLING ACROSS THE PLASMA MEMBRANE INTITL 2 ACTIVATION OF THE EGF RECEPTOR.REF CELL(CAMBRIDGE,MASS.) V. 152 543 2013REFN ISSN 0092-8674PMID 23374349DOI 10.1016/J.CELL.2012.12.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3s2k DKK1 structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6. 2.8Å AUTH V.E.AHN,M.L.CHU,H.J.CHOI,D.TRAN,A.ABO,W.I.WEISTITL STRUCTURAL BASIS OF WNT SIGNALING INHIBITION BY DICKKOPFTITL 2 BINDING TO LRP5/6.REF DEV.CELL V. 21 862 2011REFN ISSN 1534-5807PMID 22000856DOI 10.1016/J.DEVCEL.2011.09.003 Variant Set Distributions Mapped Variants
General Structure Information 3s2k LRP6 structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6. 2.8Å AUTH V.E.AHN,M.L.CHU,H.J.CHOI,D.TRAN,A.ABO,W.I.WEISTITL STRUCTURAL BASIS OF WNT SIGNALING INHIBITION BY DICKKOPFTITL 2 BINDING TO LRP5/6.REF DEV.CELL V. 21 862 2011REFN ISSN 1534-5807PMID 22000856DOI 10.1016/J.DEVCEL.2011.09.003 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2iwn MPDZ 3rd pdz domain of multiple pdz domain protein mpdz (casp target) 1.35Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,AUTH 2 C.PHILLIPS,C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINEDTITL 2 WITH THE HELP OF SELF-BINDING C-TERMINALTITL 3 EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2iwp MPDZ 12th pdz domain of multiple pdz domain protein mpdz (casp target) 2.15Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2dkx SPDEF solution structure of the sam_pnt-domain of ets transcription factor pdef (prostate ets) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF ETSTITL 2 TRANSCRIPTION FACTOR PDEF (PROSTATE ETS)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qg1 MPDZ crystal structure of the 11th pdz domain of mpdz (mupp1) 1.4Å AUTH E.PAPAGRIGORIOU,E.SALAH,C.PHILLIPS,P.SAVITSKY,AUTH 2 P.BOISGUERIN,H.OSCHKINAT,C.GILEADI,X.YANG,AUTH 3 J.M.ELKINS,E.UGOCHUKWU,G.BUNKOCZI,J.UPPENBERG,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZTITL 2 (MUPP1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t6a BCAR3 structure of the c-terminal domain of bcar3 2.4Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t5i PDE6D structure of fully modified farnesylated rheb peptide in complex with pde6d 2.1Å AUTH S.A.ISMAIL,Y.X.CHEN,A.RUSINOVA,A.CHANDRA,M.BIERBAUM,AUTH 2 L.GREMER,G.TRIOLA,H.WALDMANN,P.I.BASTIAENS,A.WITTINGHOFERTITL ARL2-GTP AND ARL3-GTP REGULATE A GDI-LIKE TRANSPORT SYSTEMTITL 2 FOR FARNESYLATED CARGO.REF NAT.CHEM.BIOL. V. 7 942 2011REFN ISSN 1552-4450PMID 22002721DOI 10.1038/NCHEMBIO.686 Variant Set Distributions Mapped Variants