Assessment of Structural Intolerance and Durability
General Structure Information 2fn4 RRAS the crystal structure of human ras-related protein, rras, in the gdp- bound state 1.65Å AUTH A.P.TURNBULL,J.M.ELKINS,C.GILEADI,N.BURGESS,E.SALAH,AUTH 2 E.PAPAGRIGORIOU,J.DEBRECZENI,F.VON DELFT,J.WEIGELT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF HUMAN RAS-RELATED PROTEIN, RRAS, INTITL 2 THE GDP-BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3rap RAP2A the small g protein rap2 in a non catalytic complex with gtp 2.2Å AUTH J.MENETREY,J.CHERFILSTITL STRUCTURE OF THE SMALL G PROTEIN RAP2 IN ATITL 2 NON-CATALYTIC COMPLEX WITH GTP.REF PROTEINS V. 37 465 1999REFN ISSN 0887-3585PMID 10591105DOI 10.1002/(SICI)1097-0134(19991115)37:33.0.CO;2-O Variant Set Distributions Mapped Variants
General Structure Information 2gco RHOC crystal structure of the human rhoc-gppnhp complex 1.4Å AUTH S.M.G.DIAS,R.A.CERIONETITL X-RAY CRYSTAL STRUCTURES REVEAL TWO ACTIVATED STATES FORTITL 2 RHOC.REF BIOCHEMISTRY V. 46 6547 2007REFN ISSN 0006-2960PMID 17497936DOI 10.1021/BI700035P Variant Set Distributions Mapped Variants
General Structure Information 4mqs CHRM2 structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo 3.5Å AUTH A.C.KRUSE,A.M.RING,A.MANGLIK,J.HU,K.HU,K.EITEL,H.HUBNER,AUTH 2 E.PARDON,C.VALANT,P.M.SEXTON,A.CHRISTOPOULOS,C.C.FELDER,AUTH 3 P.GMEINER,J.STEYAERT,W.I.WEIS,K.C.GARCIA,J.WESS,B.K.KOBILKATITL ACTIVATION AND ALLOSTERIC MODULATION OF A MUSCARINICTITL 2 ACETYLCHOLINE RECEPTOR.REF NATURE V. 504 101 2013REFN ISSN 0028-0836PMID 24256733DOI 10.1038/NATURE12735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2edy PTPRF solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f -1.0Å AUTH M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r4s ADRB2 crystal structure of the human beta2 adrenoceptor 3.4Å AUTH S.G.F.RASMUSSEN,H.J.CHOI,D.M.ROSENBAUM,T.S.KOBILKA,AUTH 2 F.S.THIAN,P.C.EDWARDS,M.BURGHAMMER,V.R.RATNALA,R.SANISHVILI,AUTH 3 R.F.FISCHETTI,G.F.SCHERTLER,W.I.WEIS,B.K.KOBILKATITL CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGICTITL 2 G-PROTEIN-COUPLED RECEPTOR.REF NATURE V. 450 383 2007REFN ISSN 0028-0836PMID 17952055DOI 10.1038/NATURE06325 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dju PTPRF solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ke5 RALB solution structure and dynamics of the small gtpase ralb in its active conformation: significance for effector protein binding -1.0Å AUTH R.B.FENWICK,S.PRASANNAN,L.J.CAMPBELL,D.NIETLISPACH,AUTH 2 K.A.EVETTS,J.CAMONIS,H.R.MOTT,D.OWENTITL SOLUTION STRUCTURE AND DYNAMICS OF THE SMALL GTPASETITL 2 RALB IN ITS ACTIVE CONFORMATION: SIGNIFICANCE FORTITL 3 EFFECTOR PROTEIN BINDINGREF BIOCHEMISTRY V. 48 2192 2009REFN ISSN 0006-2960PMID […]
General Structure Information 2ode GNAI3 crystal structure of the heterodimeric complex of human rgs8 and activated gi alpha 3 1.9Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 2cso PLEK solution structure of the dep domain of human pleckstrin -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEP DOMAIN OF HUMANTITL 2 PLECKSTRINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants