Assessment of Structural Intolerance and Durability
General Structure Information 1w1f LYN sh3 domain of human lyn tyrosine kinase -1.0Å AUTH F.BAUER,K.SCHWEIMER,H.MEISELBACH,S.HOFFMANN,AUTH 2 P.ROESCH,H.STICHTTITL STRUCTURAL CHARACTERIZATION OF LYN-SH3 DOMAIN INTITL 2 COMPLEX WITH A HERPESVIRAL PROTEIN REVEALS ANTITL 3 EXTENDED RECOGNITION MOTIF THAT ENHANCES BINDINGTITL 4 AFFINITY.REF PROTEIN SCI. V. 14 2487 2005REFN ISSN 0961-8368PMID 16155203DOI 10.1110/PS.051563605 Variant Set Distributions Mapped Variants
General Structure Information 2zm1 LCK crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) 2.1Å AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. […]
General Structure Information 4bpb DDX58 structural insights into rna recognition by rig-i 2.58Å AUTH D.LUO,S.C.DING,A.VELA,A.KOHLWAY,B.D.LINDENBACH,A.M.PYLETITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY RIG-I.REF CELL(CAMBRIDGE,MASS.) V. 147 409 2011REFN ISSN 0092-8674PMID 22000018DOI 10.1016/J.CELL.2011.09.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1eer EPO crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms 1.9Å AUTH R.S.SYED,S.W.REID,C.LI,J.C.CHEETHAM,K.H.AOKI,B.LIU,AUTH 2 H.ZHAN,T.D.OSSLUND,A.J.CHIRINO,J.ZHANG,AUTH 3 J.FINER-MOORE,S.ELLIOTT,K.SITNEY,B.A.KATZ,AUTH 4 D.J.MATTHEWS,J.J.WENDOLOSKI,J.EGRIE,R.M.STROUDTITL EFFICIENCY OF SIGNALLING THROUGH CYTOKINETITL 2 RECEPTORS DEPENDS CRITICALLY ON RECEPTORTITL 3 ORIENTATION.REF NATURE V. 395 511 1998REFN ISSN 0028-0836PMID 9774108DOI 10.1038/26773 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1d4t SH2D1A crystal structure of the xlp protein sap in complex with a slam peptide 1.1Å AUTH F.POY,M.B.YAFFE,J.SAYOS,K.SAXENA,M.MORRA,J.SUMEGI,AUTH 2 L.C.CANTLEY,C.TERHORST,M.J.ECKTITL CRYSTAL STRUCTURES OF THE XLP PROTEIN SAP REVEAL ATITL 2 CLASS OF SH2 DOMAINS WITH EXTENDED,TITL 3 PHOSPHOTYROSINE-INDEPENDENT SEQUENCE RECOGNITION.REF MOL.CELL V. 4 555 1999REFN ISSN 1097-2765PMID 10549287DOI 10.1016/S1097-2765(00)80206-3 Variant Set Distributions […]
General Structure Information 1w1h PDPK1 crystal structure of the pdk1 pleckstrin homology (ph) domain 1.45Å AUTH D.KOMANDER,A.FAIRSERVICE,M.DEAK,G.S.KULAR,AUTH 2 A.R.PRESCOTT,C.P.DOWNES,S.T.SAFRANY,D.R.ALESSI,AUTH 3 D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE REGULATION OF PDK1 BYTITL 2 PHOSPHOINOSITIDES AND INOSITOL PHOSPHATESREF EMBO J. V. 23 3918 2004REFN ISSN 0261-4189PMID 15457207DOI 10.1038/SJ.EMBOJ.7600379 Variant Set Distributions Mapped Variants
General Structure Information 4o7q AIM2 crystal structure of the f27g aim2 pyrin domain mutant and similarities of its self-association to ded/ded interactions 1.82Å AUTH A.LU,V.KABALEESWARAN,T.FU,V.G.MAGUPALLI,H.WUTITL CRYSTAL STRUCTURE OF THE F27G AIM2 PYD MUTANT ANDTITL 2 SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DEDTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 426 1420 2014REFN ISSN 0022-2836PMID 24406744DOI 10.1016/J.JMB.2013.12.029 Variant Set Distributions […]
General Structure Information 1wx6 NCK2 solution structure of the sh3 domain of the human cytoplasmic protein nck2 -1.0Å AUTH S.OHNISHI,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 CYTOPLASMIC PROTEIN NCK2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sua PLXNB1 crystal structure of the intracellular domain of plexin-b1 in complex with rac1 4.39Å AUTH C.H.BELL,A.R.ARICESCU,E.Y.JONES,C.SIEBOLDTITL A DUAL BINDING MODE FOR RHOGTPASES IN PLEXIN SIGNALLING.REF PLOS BIOL. V. 9 01134 2011REFN ISSN 1544-9173PMID 21912513DOI 10.1371/JOURNAL.PBIO.1001134 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wjm SPTBN2 solution structure of pleckstrin homology domain of human beta iii spectrin. -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF PLECKSTRIN HOMOLOGY DOMAINTITL 2 OF HUMAN BETA III SPECTRINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants