1WX6.A | NCK2 – ASTRID

1WX6.A | NCK2

PDB ID	1wx6
HGNC Gene Label(s)	NCK2
Structure Name	solution structure of the sh3 domain of the human cytoplasmic protein nck2
Resolution	-1.0Å
Reference	AUTH S.OHNISHI,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 CYTOPLASMIC PROTEIN NCK2REF TO BE PUBLISHEDREFN

ExAC Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:106498120		L>P	A:8	(-5.31, -16.10, 14.47)
2:106498126		N>S	A:10	(-4.12, -15.51, 6.59)
2:106498132		Q>R	A:12	(-3.97, -14.69, 0.59)
2:106498134	rs376669820	G>S	A:13	(-1.35, -13.46, -2.93)
2:106498143	COSM2981295 COSM2981294	V>M	A:16	(-2.20, -1.94, -0.81)
2:106498144		V>A	A:16	(-2.20, -1.94, -0.81)
2:106498147		L>P	A:17	(-3.34, -3.32, -6.35)
2:106498149	COSM1398599 COSM1398598	H>Y	A:18	(-4.44, 1.01, -6.88)
2:106498150	COSM4132938 COSM4132937	H>P	A:18	(-4.44, 1.01, -6.88)
2:106498162		T>M	A:22	(-16.80, 4.11, 0.09)
2:106498179		S>A	A:28	(-24.13, -7.27, 1.30)
2:106498180		S>L	A:28	(-24.13, -7.27, 1.30)
2:106498182		V>F	A:29	(-27.23, -10.27, 3.07)
2:106498194		E>K	A:33	(-21.34, -8.75, -2.08)
2:106498201		N>S	A:35	(-20.14, -5.58, 3.89)
2:106498222		M>T	A:42	(-12.30, -0.17, 1.25)
2:106498275		A>P	A:60	(-12.03, -2.32, 8.53)
2:106498276		A>V	A:60	(-12.03, -2.32, 8.53)
2:106498279		R>Q	A:61	(-15.73, -5.42, 10.08)
2:106498303		K>R	A:69	(-16.25, -0.05, -11.18)
2:106498317		V>I	A:74	(-8.68, 5.24, -7.64)
2:106498328	COSM1669193 COSM144110 COSM1669192	D>E	A:77	(-1.66, 4.97, -7.18)
2:106498329		G>R	A:78	(-0.14, 2.94, -3.71)
2:106498330		G>E	A:78	(-0.14, 2.94, -3.71)
2:106498333	rs137868721	P>L	A:79	(1.19, 1.73, -0.24)
2:106498342		H>R	A:82	(3.69, 7.18, -6.42)
2:106498344		P>S	A:83	(6.09, 11.67, -4.91)
2:106498351		H>R	A:85	(0.72, 16.35, 1.26)
2:106498352	rs377759138	H>Q	A:85	(0.72, 16.35, 1.26)