Assessment of Structural Intolerance and Durability
General Structure Information 2i3y GPX5 crystal structure of human glutathione peroxidase 5 2.0Å AUTH K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pxx ECE2 human putative methyltransferase mgc2408 1.3Å AUTH W.TEMPEL,H.WU,L.DOMBROVSKY,H.ZENG,P.LOPPNAU,H.ZHU,AUTH 2 A.N.PLOTNIKOV,A.BOCHKAREVTITL AN INTACT SAM-DEPENDENT METHYLTRANSFERASE FOLD ISTITL 2 ENCODED BY THE HUMAN ENDOTHELIN-CONVERTING ENZYME-2TITL 3 GENE.REF PROTEINS V. 74 789 2009REFN ISSN 0887-3585PMID 19089949DOI 10.1002/PROT.22299 Variant Set Distributions Mapped Variants
General Structure Information 3i2v MOCS3 crystal structure of human mocs3 rhodanese-like domain 1.25Å AUTH J.P.BACIK,J.R.WALKER,L.LOPEZ,Y.LI,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN MOCS3 RHODANESE-LIKETITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hrb CBR3 crystal structure of human carbonyl reductase 3, complexed with nadp+ 1.9Å AUTH E.S.PILKA,A.ROJKOVA,K.L.KAVANAGH,F.NIESEN,M.SUNDSTROM,AUTH 2 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN CARBONYL REDUCTASE 3, COMPLEXEDTITL 2 WITH NADP+REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2f6q ECI2 the crystal structure of human peroxisomal delta3, delta2 enoyl coa isomerase (peci) 1.95Å AUTH A.TURNBULL,P.LUKACIK,N.SHAFQAT,C.SMEE,G.BERRIDGE,K.GUO,AUTH 2 F.VON DELFT,J.WEIGELT,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 O.GILEADI,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3, DELTA2TITL 2 ENOYL COA ISOMERASE (PECI)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3mtg AHCYL1 crystal structure of human s-adenosyl homocysteine hydrolase-like 1 protein 2.64Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,P.SCHUTZ,AUTH 5 A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN S-ADENOSYL HOMOCYSTEINETITL 2 HYDROLASE-LIKE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2o2t MPDZ the crystal structure of the 1st pdz domain of mpdz 2.7Å AUTH E.PAPAGRIGORIOU,C.GILEADI,C.PHILLIPS,J.ELKINS,C.JOHANSSON,AUTH 2 E.SALAH,P.SAVITSKY,G.BERRIDGE,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE 1ST PDZ DOMAIN OF MPDZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3k27 EED complex structure of eed and trimethylated h3k9 1.76Å AUTH C.XU,C.BIAN,W.YANG,M.GALKA,H.OUYANG,C.CHEN,W.QIU,H.LIU,AUTH 2 A.E.JONES,F.MACKENZIE,P.PAN,S.S.LI,H.WANG,J.MINTITL BINDING OF DIFFERENT HISTONE MARKS DIFFERENTIALLY REGULATESTITL 2 THE ACTIVITY AND SPECIFICITY OF POLYCOMB REPRESSIVE COMPLEXTITL 3 2 (PRC2).REF PROC.NATL.ACAD.SCI.USA V. 107 19266 2010REFN ISSN 0027-8424PMID 20974918DOI 10.1073/PNAS.1008937107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3kfv TJP3 crystal structure of the sh3-kinase fragment of tight junction protein 3 (tjp3) in apo-form 2.8Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,N.ZHONG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE SH3-KINASE FRAGMENT OFTITL 2 TIGHT JUNCTION PROTEIN 3 (TJP3) IN APO-FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dal PRDM1 methyltransferase domain of human pr domain-containing protein 1 1.65Å AUTH H.ZENG,M.F.AMAYA,T.ANTOSHENKO,A.DONG,P.LOPPNAU,AUTH 2 A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants