Assessment of Structural Intolerance and Durability
General Structure Information 3l50 GMFG the crystal structure of human glia maturation factor, gamma (gmfg) 1.9Å AUTH E.UGOCHUKWU,E.PILKA,E.KRYSZTOFINSKA,E.HAPKA,T.KROJER,AUTH 2 J.MUNIZ,M.VOLLMAR,A.C.W.PIKE,F.VON DELFT,K.L.KAVANAGH,AUTH 3 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GLIA MATURATION FACTOR, GAMMATITL 2 (GMFG)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fyt PRMT3 human hmt1 hnrnp methyltransferase-like 3 (s. cerevisiae) protein 2.0Å AUTH H.WU,J.R.MIN,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE 3 IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lg7 MBD4 crystal structure mbd4 mbd domain in complex with methylated cpg dna 2.5Å AUTH C.XU,W.TEMPEL,A.K.WERNIMONT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE MBD4 MBD DOMAIN IN COMPLEX WITH METHYLATEDTITL 2 CPG DNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2opg MPDZ the crystal structure of the 10th pdz domain of mpdz 1.5Å AUTH C.GILEADI,C.PHILLIPS,J.ELKINS,E.PAPAGRIGORIOU,AUTH 2 E.UGOCHUKWU,F.GORREC,P.SAVITSKY,C.UMEANO,AUTH 3 G.BERRIDGE,O.GILEADI,E.SALAH,A.EDWARDS,AUTH 4 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.A.DOYLE,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF THE 10TH PDZ DOMAIN OFTITL 2 MPDZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gwh SULT1C4 human sulfotranferase sult1c2 in complex with pap and pentachlorophenol 1.8Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2iwq MPDZ 7th pdz domain of multiple pdz domain protein mpdz 1.8Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 3pfn NADK crystal structure of human nad kinase 2.7Å AUTH H.WANG,W.TEMPEL,A.K.WERNIMONT,Y.TONG,X.GUAN,Y.SHEN,Y.LI,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN NAD KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qve HBP1 crystal structure of human hmg box-containing protein 1, hbp1 2.04Å AUTH A.CHAIKUAD,E.KRYSZTOFINSKA,R.COCKING,M.VOLLMAR,W.W.YUE,AUTH 2 T.KROJER,E.UGOCHUKWU,P.FILIPPAKOPOULOS,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,C.BOUNTRA,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUMTITL CRYSTAL STRUCTURE OF HUMAN HMG BOX-CONTAINING PROTEIN 1,TITL 2 HBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nzj REM1 the crystal structure of rem1 in complex with gdp 2.5Å AUTH A.P.TURNBULL,E.PAPAGRIGORIOU,E.UGOCHUKWU,J.M.ELKINS,AUTH 2 M.SOUNDARARAJAN,X.YANG,F.GORREC,C.UMEANO,E.SALAH,N.BURGESS,AUTH 3 C.JOHANSSON,G.BERRIDGE,O.GILEADI,J.BRAY,B.MARSDEN,S.WATTS,AUTH 4 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,M.SUNDSTROM,AUTH 5 D.DOYLETITL THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bkw ZFYVE9 crystal structure of the c-terminal region of human zfyve9 2.53Å AUTH E.WILLIAMSTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMAN ZFYVE9REF PH D THESIS 2013PUBL NULL: UNIVERSITY OF OXFORD (THESIS) Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants