Assessment of Structural Intolerance and Durability
General Structure Information 2gf9 RAB3D crystal structure of human rab3d in complex with gdp 1.53Å AUTH B.HONG,J.WANG,L.SHEN,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB3D IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kci HERC2 the third rld domain of herc2 1.8Å AUTH J.R.WALKER,L.QIU,A.VESTERBERG,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE THIRD RLD DOMAIN OF HERC2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ax4 PAPSS2 crystal structure of the kinase domain of human 3- phosphoadenosine 5-phosphosulphate synthetase 2 2.5Å AUTH W.M.RABEH,L.NEDYALKOVA,S.ISMAIL,H.PARK,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREVTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF PAPSS 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q3e UGDH structure of human udp-glucose dehydrogenase complexed with nadh and udp-glucose 2.0Å AUTH S.EGGER,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANN,B.NIDETZKYTITL STRUCTURE AND MECHANISM OF HUMAN UDP-GLUCOSETITL 2 6-DEHYDROGENASE.REF J.BIOL.CHEM. V. 286 23877 2011REFN ISSN 0021-9258PMID 21502315DOI 10.1074/JBC.M111.234682 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2iwn MPDZ 3rd pdz domain of multiple pdz domain protein mpdz (casp target) 1.35Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,AUTH 2 C.PHILLIPS,C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINEDTITL 2 WITH THE HELP OF SELF-BINDING C-TERMINALTITL 3 EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2iwp MPDZ 12th pdz domain of multiple pdz domain protein mpdz (casp target) 2.15Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 4jxm RRP9 crystal structure of rrp9 wd40 repeats 1.92Å AUTH X.WU,W.TEMPEL,C.XU,M.EL BAKKOURI,H.HE,Y.LI,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF RRP9 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lm0 STK17B crystal structure of human serine/threonine kinase 17b (stk17b) 2.35Å Variant Set Distributions Mapped Variants
General Structure Information 2qg1 MPDZ crystal structure of the 11th pdz domain of mpdz (mupp1) 1.4Å AUTH E.PAPAGRIGORIOU,E.SALAH,C.PHILLIPS,P.SAVITSKY,AUTH 2 P.BOISGUERIN,H.OSCHKINAT,C.GILEADI,X.YANG,AUTH 3 J.M.ELKINS,E.UGOCHUKWU,G.BUNKOCZI,J.UPPENBERG,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZTITL 2 (MUPP1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fo9 PIAS2 crystal structure of the e3 sumo ligase pias2 2.39Å AUTH J.HU,A.DONG,E.DOBROVETSKY,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE E3 SUMO LIGASE PIAS2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants