General Structure Information 2r2p EPHA5 kinase domain of human ephrin type-a receptor 5 (epha5) 2.4Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f5y RGS3 crystal structure of the pdz domain from human rgs-3 2.39Å AUTH E.UGOCHUKWU,G.BERRIDGE,C.JOHANSSON,C.SMEE,P.SAVITSKY,AUTH 2 N.BURGESS,S.COLEBROOK,X.YANG,J.ELKINS,D.DOYLE,A.TURNBULL,AUTH 3 E.PAPAGRIGORIOU,J.DEBRECZENI,G.BUNKOCZI,F.GORREC,AUTH 4 F.VON DELFT,C.ARROWSMITH,M.SUNDSTROM,J.WEIGELT,A.EDWARDSTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nr9 CLK2 structure of human cdc2-like kinase 2 (clk2) 2.89Å AUTH A.CHAIKUAD,P.SAVITSKY,T.KROJER,J.R.C.MUNIZ,AUTH 2 P.FILIPPAKOPOULOS,P.RELLOS,T.KEATES,O.FEDOROV,A.C.W.PIKE,AUTH 3 J.ESWARAN,G.BERRIDGE,C.PHILLIPS,Y.ZHANG,F.VON DELFT,AUTH 4 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gs3 GPX4 crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(gpx4) 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,A.ROJKOVA,O.GILEADI,F.VON DELFT,AUTH 2 C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OFTITL 2 HUMAN GLUTATHIONE PEROXIDASE 4(GPX4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a9u USP8 structure of the n-terminal domain of human ubiquitin carboxyl-terminal hydrolase 8 (usp8) 2.1Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,AUTH 2 F.MACKENZIE,E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESETITL 2 INTERACTION, AND INHIBITED CATALYTIC DOMAINTITL 3 CONFORMATION OF THE UBIQUITIN-SPECIFIC PROTEASE 8TITL 4 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Mapped Variants
General Structure Information 2gf2 HIBADH crystal structure of human hydroxyisobutyrate dehydrogenase 2.38Å AUTH E.PAPAGRIGORIOU,E.SALAH,A.P.TURNBULL,C.SMEE,AUTH 2 N.BURGESS,O.GILEADI,F.VON DELFT,F.GORREC,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,A.M.EDWARDS,AUTH 4 U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN HYDROXYISOBUTYRATETITL 2 DEHYDROGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n9v INPP5B crystal structure of inpp5b 2.65Å AUTH L.TRESAUGUES,C.SILVANDER,S.FLODIN,M.WELIN,T.NYMAN,AUTH 2 S.GRASLUND,M.HAMMARSTROM,H.BERGLUND,P.NORDLUNDTITL STRUCTURAL BASIS FOR PHOSPHOINOSITIDE SUBSTRATE RECOGNITION,TITL 2 CATALYSIS, AND MEMBRANE INTERACTIONS IN HUMAN INOSITOLTITL 3 POLYPHOSPHATE 5-PHOSPHATASESREF STRUCTURE V. 22 744 2014REFN ISSN 0969-2126PMID 24704254DOI 10.1016/J.STR.2014.01.013 Variant Set Distributions Mapped Variants
General Structure Information 3lmk GRM5 ligand binding domain of metabotropoc glutamate receptor mglur5 complexed with glutamate 2.44Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COMPLEXED WITHTITL 2 GLUTAMATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants