Assessment of Structural Intolerance and Durability
General Structure Information 4h4f CTRC crystal structure of human chymotrypsin c (ctrc) bound to inhibitor eglin c from hirudo medicinalis 1.9Å AUTH J.BATRA,A.SZABO,T.R.CAULFIELD,A.S.SOARES,M.SAHIN-TOTH,AUTH 2 E.S.RADISKYTITL LONG-RANGE ELECTROSTATIC COMPLEMENTARITY GOVERNS SUBSTRATETITL 2 RECOGNITION BY HUMAN CHYMOTRYPSIN C, A KEY REGULATOR OFTITL 3 DIGESTIVE ENZYME ACTIVATION.REF J.BIOL.CHEM. V. 288 9848 2013REFN ISSN 0021-9258PMID 23430245DOI 10.1074/JBC.M113.457382 Variant Set […]
General Structure Information 3b7k ACOT12 human acyl-coenzyme a thioesterase 12 2.7Å AUTH L.LEHTIO,R.D.BUSAM,C.H.ARROWSMITH,R.COLLINS,L.G.DAHLGREN,AUTH 2 A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 3 B.M.HALLBERG,M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,M.SUNDSTROM,SVENSSON L.,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.BERGLUNDTITL HUMAN ACYL-COENZYME A THIOESTERASE 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lo6 KLK6 human kallikrein 6 (hk6) active form with benzamidine inhibitor at 1.56 a resolution 1.56Å AUTH M.J.BERNETT,S.I.BLABER,I.A.SCARISBRICK,AUTH 2 P.DHANARAJAN,S.M.THOMPSON,M.BLABERTITL CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATIONTITL 2 OF HUMAN KALLIKREIN 6 REVEALS A TRYPSIN-LIKETITL 3 KALLIKREIN IS EXPRESSED IN THE CENTRAL NERVOUSTITL 4 SYSTEMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2rkb SDSL serine dehydratase like-1 from human cancer cells 2.8Å AUTH T.YAMADA,J.KOMOTO,T.KASUYA,Y.TAKATA,H.OGAWA,H.MORI,AUTH 2 F.TAKUSAGAWATITL A CATALYTIC MECHANISM THAT EXPLAINS A LOW CATALYTIC ACTIVITYTITL 2 OF SERINE DEHYDRATASE LIKE-1 FROM HUMAN CANCER CELLS:TITL 3 CRYSTAL STRUCTURE AND SITE-DIRECTED MUTAGENESIS STUDIES.REF BIOCHIM.BIOPHYS.ACTA V.1780 809 2008REFN ISSN 0006-3002PMID 18342636DOI 10.1016/J.BBAGEN.2008.01.020 Variant Set Distributions Ripley’s K […]
General Structure Information 1tki TTN autoinhibited serine kinase domain of the giant muscle protein titin 2.0Å AUTH O.MAYANS,P.F.VAN DER VEN,M.WILM,A.MUES,P.YOUNG,AUTH 2 D.O.FURST,M.WILMANNS,M.GAUTELTITL STRUCTURAL BASIS FOR ACTIVATION OF THE TITINTITL 2 KINASE DOMAIN DURING MYOFIBRILLOGENESIS.REF NATURE V. 395 863 1998REFN ISSN 0028-0836PMID 9804419DOI 10.1038/27603 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3k2i ACOT4 human acyl-coenzyme a thioesterase 4 2.4Å AUTH M.I.SIPONEN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,P.KRAULIS,T.KOTENYOVA,AUTH 5 A.KOTZSCH,N.MARKOVA,T.K.NIELSEN,P.NORDLUND,T.NYMAN,AUTH 6 C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,AUTH 7 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,AUTH 8 E.WAHLBERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,H.SCHULERTITL HUMAN ACYL-COENZYME A THIOESTERASE 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 4if8 SERPINA12 structure of vaspin 2.08Å AUTH J.T.HEIKER,N.KLOTING,P.KOVACS,E.B.KUETTNER,N.STRATER,AUTH 2 S.SCHULTZ,M.KERN,M.STUMVOLL,M.BLUHER,A.G.BECK-SICKINGERTITL VASPIN INHIBITS KALLIKREIN 7 BY SERPIN MECHANISMREF CELL.MOL.LIFE SCI. V. 70 2569 2013REFN ISSN 1420-682XPMID 23370777DOI 10.1007/S00018-013-1258-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i6l MAPK6 crystal structure of human mitogen activated protein kinase 6 (mapk6) 2.25Å AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,P.SAVITSKY,AUTH 2 O.FEDOROV,G.BERRIDGE,S.DAS,J.ELKINS,AUTH 3 M.SOUNDARARAJAN,X.W.YANG,D.DOYLE,E.PAPAGRIGORIOU,AUTH 4 A.C.W.PIKE,G.BUNKONCZI,E.UGOCHUKWU,J.DEBRECZENI,AUTH 5 F.VON DELFT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 6 S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN MITOGEN ACTIVATEDTITL 2 PROTEIN KINASE 6REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]