Assessment of Structural Intolerance and Durability
General Structure Information 2hlq BMPR2 crystal structure of the extracellular domain of the type ii bmp receptor 1.45Å AUTH P.D.MACE,J.F.CUTFIELD,S.M.CUTFIELDTITL HIGH RESOLUTION STRUCTURES OF THE BONETITL 2 MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN TWOTITL 3 CRYSTAL FORMS: IMPLICATIONS FOR LIGAND BINDINGREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 351 831 2006REFN ISSN 0006-291XPMID 17094948DOI 10.1016/J.BBRC.2006.10.109 Variant Set Distributions Mapped Variants
General Structure Information 1qkq CLC charcot-leyden crystal protein – mannose complex 1.8Å AUTH G.J.SWAMINATHAN,D.D.LEONIDAS,M.P.SAVAGE,AUTH 2 S.J.ACKERMAN,K.R.ACHARYATITL SELECTIVE RECOGNITION OF MANNOSE BY THE HUMANTITL 2 EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEINTITL 3 (GALECTIN-10): A CRYSTALLOGRAPHIC STUDY AT 1.8 ATITL 4 RESOLUTIONREF BIOCHEMISTRY V. 38 13837 1999REFN ISSN 0006-2960PMID 10563827 Variant Set Distributions Mapped Variants
General Structure Information 1z68 FAP crystal structure of human fibroblast activation protein alpha 2.6Å AUTH K.AERTGEERTS,I.LEVIN,L.SHI,G.P.SNELL,A.JENNINGS,G.S.PRASAD,AUTH 2 Y.ZHANG,M.L.KRAUS,S.SALAKIAN,V.SRIDHAR,R.WIJNANDS,AUTH 3 M.G.TENNANTTITL STRUCTURAL AND KINETIC ANALYSIS OF THE SUBSTRATE SPECIFICITYTITL 2 OF HUMAN FIBROBLAST ACTIVATION PROTEIN ALPHA.REF J.BIOL.CHEM. V. 280 19441 2005REFN ISSN 0021-9258PMID 15809306DOI 10.1074/JBC.C500092200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4dgj TMPRSS15 structure of a human enteropeptidase light chain variant 1.9Å AUTH P.SIMEONOV,M.ZAHN,N.STRATER,T.ZUCHNERTITL CRYSTAL STRUCTURE OF A SUPERCHARGED VARIANT OF THE HUMANTITL 2 ENTEROPEPTIDASE LIGHT CHAIN.REF PROTEINS V. 80 1907 2012REFN ISSN 0887-3585PMID 22488687DOI 10.1002/PROT.24084 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qkq CLC charcot-leyden crystal protein – mannose complex 1.8Å AUTH G.J.SWAMINATHAN,D.D.LEONIDAS,M.P.SAVAGE,AUTH 2 S.J.ACKERMAN,K.R.ACHARYATITL SELECTIVE RECOGNITION OF MANNOSE BY THE HUMANTITL 2 EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEINTITL 3 (GALECTIN-10): A CRYSTALLOGRAPHIC STUDY AT 1.8 ATITL 4 RESOLUTIONREF BIOCHEMISTRY V. 38 13837 1999REFN ISSN 0006-2960PMID 10563827 Variant Set Distributions Mapped Variants
General Structure Information 1z68 FAP crystal structure of human fibroblast activation protein alpha 2.6Å AUTH K.AERTGEERTS,I.LEVIN,L.SHI,G.P.SNELL,A.JENNINGS,G.S.PRASAD,AUTH 2 Y.ZHANG,M.L.KRAUS,S.SALAKIAN,V.SRIDHAR,R.WIJNANDS,AUTH 3 M.G.TENNANTTITL STRUCTURAL AND KINETIC ANALYSIS OF THE SUBSTRATE SPECIFICITYTITL 2 OF HUMAN FIBROBLAST ACTIVATION PROTEIN ALPHA.REF J.BIOL.CHEM. V. 280 19441 2005REFN ISSN 0021-9258PMID 15809306DOI 10.1074/JBC.C500092200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4dgj TMPRSS15 structure of a human enteropeptidase light chain variant 1.9Å AUTH P.SIMEONOV,M.ZAHN,N.STRATER,T.ZUCHNERTITL CRYSTAL STRUCTURE OF A SUPERCHARGED VARIANT OF THE HUMANTITL 2 ENTEROPEPTIDASE LIGHT CHAIN.REF PROTEINS V. 80 1907 2012REFN ISSN 0887-3585PMID 22488687DOI 10.1002/PROT.24084 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1aye CPA2 human procarboxypeptidase a2 1.8Å AUTH I.GARCIA-SAEZ,D.REVERTER,J.VENDRELL,F.X.AVILES,AUTH 2 M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 PROCARBOXYPEPTIDASE A2. DECIPHERING THE BASIS OFTITL 3 THE INHIBITION, ACTIVATION AND INTRINSIC ACTIVITYTITL 4 OF THE ZYMOGEN.REF EMBO J. V. 16 6906 1997REFN ISSN 0261-4189PMID 9384570DOI 10.1093/EMBOJ/16.23.6906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3hlk ACOT2 crystal structure of human mitochondrial acyl-coa thioesterase (acot2) 2.1Å AUTH C.R.MANDEL,B.TWEEL,L.TONGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ACYL-COATITL 2 THIOESTERASE (ACOT2)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 385 630 2009REFN ISSN 0006-291XPMID 19497300DOI 10.1016/J.BBRC.2009.05.122 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mzd GZMK crystal structure of human pro-granzyme k 2.9Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,E.WILHARM,AUTH 2 P.FUENTES-PRIOR,W.KLINKERT,W.BODE,D.E.JENNETITL THE 2.2-A CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYMETITL 2 K REVEALS A RIGID ZYMOGEN WITH UNUSUAL FEATURESREF J.BIOL.CHEM. V. 277 50923 2002REFN ISSN 0021-9258PMID 12384499DOI 10.1074/JBC.M207962200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants