1Z68.A | FAP – ASTRID

1Z68.A | FAP

General Structure Information

PDB ID	1z68
HGNC Gene Label(s)	FAP
Structure Name	crystal structure of human fibroblast activation protein alpha
Resolution	2.6Å
Reference	AUTH K.AERTGEERTS,I.LEVIN,L.SHI,G.P.SNELL,A.JENNINGS,G.S.PRASAD,AUTH 2 Y.ZHANG,M.L.KRAUS,S.SALAKIAN,V.SRIDHAR,R.WIJNANDS,AUTH 3 M.G.TENNANTTITL STRUCTURAL AND KINETIC ANALYSIS OF THE SUBSTRATE SPECIFICITYTITL 2 OF HUMAN FIBROBLAST ACTIVATION PROTEIN ALPHA.REF J.BIOL.CHEM. V. 280 19441 2005REFN ISSN 0021-9258PMID 15809306DOI 10.1074/JBC.C500092200

Variant Set Distributions

ExAC Variants

Number Of Residues	719
Number Of SNVs	180
Number Of Permutations	29368
Optimal Distance Threshold	6.0
K Statistic	0.007
p-value	0.47

COSMIC

Number Of Residues	719
Number Of SNVs	16
Number Of Permutations	19884
Optimal Distance Threshold	20.0
K Statistic	0.225
p-value	0.297

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	180
Number Of COSMIC SNVs	13
Optimal Distance Threshold	7.0
K Statistic	0.027
p-value	0.708

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:163083087	rs375223006	D>N	A:46	(13.45, -9.78, 64.39)
2:163083074		G>A	A:50	(16.21, -4.58, 67.60)
2:163083045	rs370535996	N>D	A:60	(28.58, 9.11, 84.81)
2:163083040		W>C	A:61	(31.58, 6.00, 88.45)
2:163083037		I>M	A:62	(30.79, 12.19, 90.07)
2:163083039		I>L	A:62	(30.79, 12.19, 90.07)
2:163082075		L>R	A:68	(25.23, 11.22, 87.29)
2:163082057		N>S	A:74	(14.20, 11.73, 80.22)
2:163082054		N>S	A:75	(15.13, 13.16, 84.93)
2:163082046	rs139492630	L>I	A:78	(23.20, 12.13, 92.54)
2:163082036		I>T	A:81	(26.81, 3.58, 96.47)
2:163082018		Y>C	A:87	(20.08, 15.02, 94.03)
2:163082019		Y>H	A:87	(20.08, 15.02, 94.03)
2:163082009	rs563343900	L>W	A:90	(19.56, 18.55, 85.52)
2:163081020		S>T	A:106	(31.56, 20.01, 87.43)
2:163081016	COSM227705	P>R	A:107	(34.36, 18.75, 89.03)
2:163081013		D>V	A:108	(32.67, 22.31, 91.34)
2:163081011	rs371304292 COSM1008370	R>W	A:109	(29.16, 17.93, 92.59)
2:163081001		V>A	A:112	(25.92, 21.23, 83.92)
2:163080992		E>G	A:115	(25.65, 18.00, 74.12)
2:163080988		S>R	A:116	(22.81, 20.83, 71.61)
2:163080986		D>G	A:117	(22.73, 21.26, 67.98)
2:163080170		L>V	A:121	(32.56, 14.44, 61.33)
2:163080161	rs149591141	Y>H	A:124	(35.48, 7.94, 67.69)
2:163080158		S>A	A:125	(34.13, 13.21, 65.31)
2:163080128		L>F	A:135	(23.40, 23.72, 89.40)
2:163076409	rs138190509	P>L	A:147	(31.27, 29.51, 70.43)
2:163076407		R>C	A:148	(26.94, 28.27, 68.50)
2:163076403	rs185902464	P>L	A:149	(29.76, 25.01, 65.80)
2:163076397	rs140351808	Q>R	A:151	(35.14, 21.03, 67.49)
2:163076391	rs376679848	L>S	A:153	(33.79, 20.93, 75.89)
2:163076369		S>R	A:160	(34.83, 24.89, 86.97)
2:163076370	rs376459419	S>N	A:160	(34.83, 24.89, 86.97)
2:163075692		A>V	A:163	(38.40, 23.45, 77.67)
2:163075678		N>Y	A:168	(40.60, 23.54, 64.29)
2:163075671		I>T	A:170	(42.80, 25.42, 72.05)
2:163075650		G>E	A:177	(31.75, 33.46, 82.19)
2:163075641		P>H	A:180	(37.32, 33.39, 75.99)
2:163075627	rs78722278	F>L	A:185	(46.16, 32.09, 67.76)
2:163075620		G>E	A:187	(43.71, 27.30, 62.74)
2:163075613		E>D	A:189	(39.09, 25.02, 57.38)
2:163075611		N>S	A:190	(40.65, 20.14, 56.42)
2:163075612	rs375835693	N>D	A:190	(40.65, 20.14, 56.42)
2:163075599		N>S	A:194	(44.96, 22.75, 67.68)
2:163075584	rs371176473	W>S	A:199	(40.36, 9.90, 59.06)
2:163074645		M>L	A:205	(46.83, 6.29, 66.85)
2:163074629		Y>C	A:210	(39.82, 13.10, 73.46)
2:163074626		A>V	A:211	(43.76, 15.99, 71.67)
2:163074624	rs62001031	L>F	A:212	(42.45, 18.12, 75.13)
2:163074587	rs202024522 COSM1737610	A>V	A:224	(47.86, 18.47, 69.87)
2:163074584		E>V	A:225	(50.16, 21.27, 66.38)
2:163074572	rs79793562	T>M	A:229	(49.47, 21.09, 54.96)
2:163074566		I>T	A:231	(48.72, 15.10, 53.88)
2:163074567		I>V	A:231	(48.72, 15.10, 53.88)
2:163074554	rs150161783	A>V	A:235	(38.34, 12.59, 46.69)
2:163074555		A>S	A:235	(38.34, 12.59, 46.69)
2:163074537		D>Y	A:241	(19.67, 16.65, 48.20)
2:163074513		N>D	A:249	(38.32, 17.17, 50.16)
2:163072510		A>V	A:255	(50.71, 3.84, 51.96)
2:163072496		P>T	A:260	(50.83, 13.54, 59.98)
2:163072493	rs148466393	V>I	A:261	(53.60, 16.85, 61.56)
2:163072486	COSM4086010	R>Q	A:263	(54.85, 20.81, 67.31)
2:163072465	COSM214101	T>I	A:270	(46.54, 29.67, 86.36)
2:163072456	rs148803327	A>V	A:273	(50.14, 35.05, 80.08)
2:163072441		Q>R	A:278	(56.44, 25.48, 76.52)
2:163072439		E>K	A:279	(57.56, 21.70, 71.95)
2:163072433	rs140132856	P>S	A:281	(60.72, 17.41, 74.68)
2:163072420		M>T	A:285	(65.23, 7.24, 69.42)
2:163072421	rs140779053	M>V	A:285	(65.23, 7.24, 69.42)
2:163072416	rs373994480	I>M	A:286	(61.48, 9.21, 68.03)
2:163070560	rs141855900	T>M	A:297	(49.58, 9.50, 80.47)
2:163070551	rs376781426 COSM1008363	T>I	A:300	(51.60, 14.06, 88.54)
2:163070544		E>D	A:302	(54.42, 18.42, 88.75)
2:163070542	COSM717212	R>Q	A:303	(56.57, 12.85, 86.70)
2:163070537		C>S	A:305	(53.61, 10.06, 79.89)
2:163070506	rs372094400 COSM3938575	V>A	A:315	(60.22, 1.08, 67.88)
2:163070503	COSM1008362	S>L	A:316	(58.03, 2.34, 71.30)
2:163070488		C>Y	A:321	(58.22, 14.55, 81.51)
2:163070480		R>G	A:324	(63.33, 22.97, 84.11)
2:163066505		T>S	A:335	(67.22, 8.35, 82.31)
2:163066493		I>T	A:339	(63.04, 1.13, 74.46)
2:163059651		F>S	A:351	(45.64, 0.57, 69.67)
2:163059640		P>S	A:355	(50.98, 3.67, 81.10)
2:163059634		F>L	A:357	(52.17, 5.50, 86.21)
2:163059624		D>V	A:360	(55.22, 5.77, 93.52)
2:163059615	COSM3568517	S>L	A:363	(56.43, 3.04, 89.08)
2:163059612		Y>C	A:364	(55.67, 1.95, 84.26)
2:163059606		K>R	A:366	(53.18, -1.61, 79.93)
2:163059592	rs200942734	K>E	A:371	(61.41, -13.34, 78.22)
2:163059588		D>G	A:372	(57.91, -17.01, 76.22)
2:163059589	COSM1691222	D>N	A:372	(57.91, -17.01, 76.22)
2:163059568	rs140297886	Y>H	A:379	(56.74, -2.65, 88.88)
2:163059563	rs377342625	I>M	A:380	(58.69, -0.74, 84.52)
2:163059560		K>N	A:381	(61.00, 0.26, 90.19)
2:163059437		I>L	A:390	(53.44, -9.35, 87.50)
2:163059407		I>V	A:400	(45.83, -2.59, 83.26)
2:163059382	rs202133611	L>P	A:408	(46.30, -4.85, 89.66)
2:163057110		F>I	A:415	(38.19, -19.56, 83.40)
2:163057098	rs376800338	P>S	A:419	(40.76, -17.49, 73.99)
2:163057077		R>G	A:426	(41.59, -7.63, 93.54)
2:163055386		S>I	A:428	(48.47, -8.04, 95.40)
2:163055380		G>V	A:430	(53.32, -4.51, 98.44)
2:163055344	rs79484073	H>R	A:442	(33.05, -19.50, 89.25)
2:163055326		C>Y	A:448	(28.89, -14.53, 82.44)
2:163055317		Y>S	A:451	(32.45, -10.06, 83.02)
2:163055300	COSM4086009	D>N	A:457	(37.13, 8.07, 91.84)
2:163055294	COSM4086008	A>T	A:459	(38.61, 2.03, 93.44)
2:163055287		Y>C	A:461	(32.22, 1.51, 95.64)
2:163055279		L>F	A:464	(31.16, -6.06, 86.61)
2:163055275		V>A	A:465	(29.60, -5.21, 82.03)
2:163051250		I>L	A:471	(21.11, -12.41, 78.57)
2:163051231	COSM3770924	H>P	A:477	(30.73, -5.38, 92.29)
2:163051223		R>C	A:480	(37.39, -4.00, 101.37)
2:163051219	rs374504692	T>I	A:481	(35.19, -7.03, 99.27)
2:163051216	rs538538276	D>G	A:482	(35.49, -7.77, 95.30)
2:163051217		D>N	A:482	(35.49, -7.77, 95.30)
2:163046262		I>V	A:485	(26.18, -4.13, 96.09)
2:163046255	rs192963947	I>N	A:487	(21.45, -6.23, 89.61)
2:163046234		L>S	A:494	(16.11, -9.75, 75.86)
2:163046232	rs201724480 COSM1136359	E>K	A:495	(14.92, -13.36, 79.96)
2:163046225		A>V	A:497	(11.27, -11.80, 74.16)
2:163046210	rs547572967	Q>L	A:502	(13.29, -21.27, 67.37)
2:163046204		P>L	A:504	(20.83, -20.43, 67.32)
2:163046199		E>K	A:506	(26.06, -20.14, 69.71)
2:163046188	rs147933561	K>N	A:509	(34.43, -26.52, 69.35)
2:163046166		T>A	A:517	(45.53, -23.75, 66.85)
2:163045677		W>R	A:519	(39.83, -21.52, 69.81)
2:163045671		K>E	A:521	(31.27, -18.89, 67.11)
2:163045656	rs183442955	P>S	A:526	(17.09, -24.95, 64.71)
2:163045645	rs144304958	D>E	A:529	(20.35, -33.92, 61.73)
2:163045638	rs370914238	K>E	A:532	(20.42, -34.17, 57.64)
2:163044848		V>L	A:549	(35.79, -16.43, 68.33)
2:163044839		V>I	A:552	(29.53, -12.21, 72.91)
2:163044836		F>L	A:553	(23.68, -12.23, 73.54)
2:163044822	COSM441320 COSM320319	W>C	A:557	(22.85, -11.89, 58.12)
2:163044821		I>V	A:558	(24.66, -15.12, 61.58)
2:163044818		S>P	A:559	(21.31, -15.80, 64.12)
2:163044814		Y>C	A:560	(17.60, -14.83, 59.38)
2:163044808		A>V	A:562	(20.24, -20.41, 61.42)
2:163044806	rs114179274	S>G	A:563	(16.71, -19.68, 62.75)
2:163044796		G>V	A:566	(19.62, -23.48, 57.44)
2:163044751		G>D	A:581	(50.41, -14.47, 71.13)
2:163044748		D>G	A:582	(53.69, -12.88, 69.63)
2:163044736		Y>C	A:586	(53.61, -10.22, 66.05)
2:163044734		A>T	A:587	(52.36, -14.43, 61.39)
2:163044731		V>M	A:588	(50.40, -11.70, 59.58)
2:163044727	rs181809917	Y>C	A:589	(55.44, -8.00, 60.36)
2:163044721		K>R	A:591	(53.19, -12.85, 54.60)
2:163044688	rs527951972	T>I	A:602	(42.19, -25.28, 56.91)
2:163039971		I>L	A:608	(33.82, -30.50, 54.66)
2:163039961	rs149046822	G>D	A:611	(29.63, -34.47, 57.55)
2:163039958	rs199927577	F>Y	A:612	(27.83, -31.22, 59.67)
2:163031470		G>R	A:626	(36.53, -9.28, 55.47)
2:163031461	rs141879753	V>I	A:629	(39.65, -12.27, 53.47)
2:163031454		S>L	A:631	(37.62, -11.76, 48.12)
2:163031392		S>G	A:652	(45.23, -2.43, 48.01)
2:163031386		E>K	A:654	(48.61, 1.56, 47.23)
2:163031377	rs142580939	A>T	A:657	(45.87, 4.00, 56.11)
2:163030283		E>Q	A:662	(52.94, 1.57, 57.37)
2:163030274		M>V	A:665	(52.45, -4.47, 55.10)
2:163030265	COSM123051	P>S	A:668	(55.42, 0.96, 49.96)
2:163030261	rs189580168	T>K	A:669	(59.53, 0.88, 49.31)
2:163030240	rs554239683	H>R	A:676	(53.03, -8.76, 49.90)
2:163030237	rs375797623	Y>S	A:677	(52.28, -3.01, 50.18)
2:163029724	COSM260839	T>I	A:681	(45.99, -7.18, 45.37)
2:163029725	rs140683015	T>A	A:681	(45.99, -7.18, 45.37)
2:163029722		V>L	A:682	(41.77, -8.37, 44.92)
2:163029717		M>I	A:683	(42.95, -6.20, 41.82)
2:163029718	rs367765256	M>T	A:683	(42.95, -6.20, 41.82)
2:163029715		A>G	A:684	(45.58, -10.11, 41.10)
2:163029716		A>S	A:684	(45.58, -10.11, 41.10)
2:163029703		Y>C	A:688	(42.32, -17.42, 39.98)
2:163029699		F>L	A:689	(36.68, -13.81, 41.44)
2:163029689		D>Y	A:693	(28.71, -16.38, 42.65)
2:163029671		G>R	A:699	(30.05, 3.21, 49.82)
2:163029665		A>T	A:701	(30.97, 8.05, 51.47)
2:163029379		Q>P	A:708	(39.95, 3.70, 45.45)
2:163029367	rs374652964	Q>P	A:712	(40.31, -0.36, 41.16)
2:163029356		A>T	A:716	(39.46, -5.97, 37.28)
2:163029349		V>A	A:718	(35.62, -5.86, 33.56)
2:163029341		Q>K	A:721	(36.02, -11.10, 29.99)
2:163029334		D>A	A:723	(29.66, -11.82, 35.93)
2:163027569		G>S	A:735	(28.52, 1.46, 58.05)
2:163027560	rs143485547	G>S	A:738	(20.29, 2.95, 58.17)
2:163027557		L>V	A:739	(16.90, 2.68, 55.59)
2:163027553	rs556310571	S>C	A:740	(21.46, 1.27, 54.00)
2:163027554		S>P	A:740	(21.46, 1.27, 54.00)
2:163027550	rs138652824	T>M	A:741	(21.38, -1.59, 57.13)
2:163027547		N>I	A:742	(17.43, -2.36, 56.23)
2:163027538		Y>F	A:745	(22.47, -6.99, 56.59)
2:163027528		M>I	A:748	(23.64, -9.83, 51.78)
2:163027509		C>S	A:755	(23.88, -19.46, 46.52)
2:163027506	rs373214740	F>V	A:756	(23.21, -21.69, 49.91)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:163076424	COSM1168899	R>I	A:142	(22.47, 34.13, 80.19)
2:163075687	COSM255822	V>I	A:165	(38.20, 23.08, 70.24)
2:163075650	COSM4988824	G>E	A:177	(31.75, 33.46, 82.19)
2:163075631	COSM3379816	I>M	A:183	(45.72, 28.48, 73.74)
2:163075597	COSM311097	G>R	A:195	(42.95, 19.27, 70.51)
2:163074648	COSM4304824	E>K	A:204	(43.82, 4.11, 62.54)
2:163074644	COSM1669336	M>T	A:205	(46.83, 6.29, 66.85)
2:163072487	COSM207531	R>W	A:263	(54.85, 20.81, 67.31)
2:163070503	COSM1008362	S>L	A:316	(58.03, 2.34, 71.30)
2:163059615	COSM3568517	S>L	A:363	(56.43, 3.04, 89.08)
2:163059452	COSM3568515	E>K	A:385	(67.08, -4.08, 81.88)
2:163046238	COSM4527612	E>K	A:493	(12.88, -6.57, 79.26)
2:163045640	COSM3568512	S>L	A:531	(22.79, -36.89, 59.50)
2:163044724	COSM1691220	R>Q	A:590	(56.77, -7.29, 56.08)
2:163031436	COSM1613578	G>E	A:637	(41.13, -21.84, 43.65)
2:163031377	COSM4533317	A>T	A:657	(45.87, 4.00, 56.11)

1Z68.A | FAP.

1Z68.A | FAP

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants