General Structure Information
| PDB ID | 3b7k |
| HGNC Gene Label(s) | ACOT12 |
| Structure Name | human acyl-coenzyme a thioesterase 12 |
| Resolution | 2.7Å |
| Reference | AUTH L.LEHTIO,R.D.BUSAM,C.H.ARROWSMITH,R.COLLINS,L.G.DAHLGREN,AUTH 2 A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 3 B.M.HALLBERG,M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,M.SUNDSTROM,SVENSSON L.,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.BERGLUNDTITL HUMAN ACYL-COENZYME A THIOESTERASE 12.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 265 |
| Number Of SNVs | 72 |
| Number Of Permutations | 35489 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.043 |
| p-value | 0.455 |
COSMIC
| Number Of Residues | 265 |
| Number Of SNVs | 4 |
| Number Of Permutations | 311 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.333 |
| p-value | 0.828 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 72 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | -0.146 |
| p-value | 0.973 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
