Assessment of Structural Intolerance and Durability
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dgc IL22RA1 structure of il-22/il-22r1 2.5Å AUTH B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL STRUCTURE OF IL-22 BOUND TO ITS HIGH-AFFINITY IL-22R1 CHAIN.REF STRUCTURE V. 16 1333 2008REFN ISSN 0969-2126PMID 18599299DOI 10.1016/J.STR.2008.06.005 Variant Set Distributions Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 3hhc IFNL3 interferon-lambda is functionally an interferon but structurally related to the il-10 family 2.8Å AUTH H.H.GAD,C.DELLGREN,O.J.HAMMING,S.VENDS,S.R.PALUDAN,AUTH 2 R.HARTMANNTITL INTERFERON-{LAMBDA} IS FUNCTIONALLY AN INTERFERONTITL 2 BUT STRUCTURALLY RELATED TO THE INTERLEUKIN-10TITL 3 FAMILYREF J.BIOL.CHEM. V. 284 20869 2009REFN ISSN 0021-9258PMID 19457860DOI 10.1074/JBC.M109.002923 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lb6 IL13RA2 the structure of il-13 in complex with il-13ralpha2 3.05Å AUTH P.J.LUPARDUS,M.E.BIRNBAUM,K.C.GARCIATITL MOLECULAR BASIS FOR SHARED CYTOKINE RECOGNITION REVEALED INTITL 2 THE STRUCTURE OF AN UNUSUALLY HIGH AFFINITY COMPLEX BETWEENTITL 3 IL-13 AND IL-13RALPHA2.REF STRUCTURE V. 18 332 2010REFN ISSN 0969-2126PMID 20223216DOI 10.1016/J.STR.2010.01.003 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3f62 IL18 crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein 2.0Å AUTH B.KRUMM,X.MENG,Y.LI,Y.XIANG,J.DENGTITL STRUCTURAL BASIS FOR ANTAGONISM OF HUMAN INTERLEUKIN 18 BYTITL 2 POXVIRUS INTERLEUKIN 18-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 105 20711 2008REFN ISSN 0027-8424PMID 19104048DOI 10.1073/PNAS.0809086106 Variant Set Distributions Mapped Variants
General Structure Information 3f62 IL18 crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein 2.0Å AUTH B.KRUMM,X.MENG,Y.LI,Y.XIANG,J.DENGTITL STRUCTURAL BASIS FOR ANTAGONISM OF HUMAN INTERLEUKIN 18 BYTITL 2 POXVIRUS INTERLEUKIN 18-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 105 20711 2008REFN ISSN 0027-8424PMID 19104048DOI 10.1073/PNAS.0809086106 Variant Set Distributions Mapped Variants
General Structure Information 3f62 IL18 crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein 2.0Å AUTH B.KRUMM,X.MENG,Y.LI,Y.XIANG,J.DENGTITL STRUCTURAL BASIS FOR ANTAGONISM OF HUMAN INTERLEUKIN 18 BYTITL 2 POXVIRUS INTERLEUKIN 18-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 105 20711 2008REFN ISSN 0027-8424PMID 19104048DOI 10.1073/PNAS.0809086106 Variant Set Distributions Mapped Variants
General Structure Information 1uv0 REG3A pancreatitis-associated protein 1 from human 1.78Å AUTH C.ABERGEL,S.CHENIVESSE,M.G.STINNAKRE,S.GUASCO,C.BRECHOT,AUTH 2 J.M.CLAVERIE,E.DEVINOY,L.CHRISTATITL CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC STUDY OFTITL 2 HIP/PAP, A HUMAN C-LECTIN OVEREXPRESSED IN PRIMARY LIVERTITL 3 CANCERS.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1487 1999REFN ISSN 0907-4449PMID 10417404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants