Assessment of Structural Intolerance and Durability
General Structure Information 2ct7 RNF31 solution structure of the ibr domain of the ring finger protein 31 protein -1.0Å AUTH K.MIYAMOTO,S.KOSHIBA,T.TOMIZAWA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IBR DOMAIN OF THE RINGTITL 2 FINGER PROTEIN 31 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ecn RNF141 solution structure of the ring domain of the human ring finger protein 141 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 RING FINGER PROTEIN 141REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yho MYLIP the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Mapped Variants
General Structure Information 2vwr LNX2 crystal structure of the second pdz domain of numb-binding protein 2 1.3Å AUTH A.K.ROOS,K.GUO,N.BURGESS-BROWN,W.W.YUE,J.M.ELKINS,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,C.H.ARROWSMITH,AUTH 3 M.WIKSTOM,A.EDWARDS,F.VON DELFT,C.BOUNTRA,D.DOYLE,AUTH 4 U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF THETITL 2 HUMAN NUMB-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 2csy RNF113B solution structure of the ring domain of the zinc finger protein 183-like 1 -1.0Å AUTH K.MIYAMOTO,M.SATO,T.TOMIZAWA,K.SAITO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE ZINCTITL 2 FINGER PROTEIN 183-LIKE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1u6g CAND1 crystal structure of the cand1-cul1-roc1 complex 3.1Å AUTH S.J.GOLDENBERG,T.C.CASCIO,S.D.SHUMWAY,K.C.GARBUTT,AUTH 2 J.LIU,Y.XIONG,N.ZHENGTITL STRUCTURE OF THE CAND1-CUL1-ROC1 COMPLEX REVEALSTITL 2 REGULATORY MECHANISMS FOR THE ASSEMBLY OF THETITL 3 MULTISUBUNIT CULLIN-DEPENDENT UBIQUITIN LIGASESREF CELL(CAMBRIDGE,MASS.) V. 119 517 2004REFN ISSN 0092-8674PMID 15537541DOI 10.1016/J.CELL.2004.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2d8s MARCH8 solution structure of the ring domain of the human cellular modulator of immune recognition protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 CELLULAR MODULATOR OF IMMUNE RECOGNITION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1ldj CUL1 structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex 3.0Å AUTH N.ZHENG,B.A.SCHULMAN,L.SONG,J.J.MILLER,P.D.JEFFREY,AUTH 2 P.WANG,C.CHU,D.M.KOEPP,S.J.ELLEDGE,M.PAGANO,AUTH 3 R.C.CONAWAY,J.W.CONAWAY,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCFTITL 2 UBIQUITIN LIGASE COMPLEX.REF NATURE V. 416 703 2002REFN ISSN 0028-0836PMID 11961546DOI 10.1038/416703A Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants