Assessment of Structural Intolerance and Durability
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jue ACAP1 crystal structure of arfgap and ank repeat domain of acap1 2.3Å AUTH M.BAI,X.PANG,J.LOU,Q.ZHOU,K.ZHANG,J.MA,J.LI,F.SUN,V.W.HSUTITL MECHANISTIC INSIGHTS INTO REGULATED CARGO BINDING BY ACAP1TITL 2 PROTEINREF J.BIOL.CHEM. V. 287 28675 2012REFN ISSN 0021-9258PMID 22645133DOI 10.1074/JBC.M112.378810 Variant Set Distributions Mapped Variants
General Structure Information 1xm9 PKP1 structure of the armadillo repeat domain of plakophilin 1 2.8Å AUTH H.J.CHOI,W.I.WEISTITL STRUCTURE OF THE ARMADILLO REPEAT DOMAIN OFTITL 2 PLAKOPHILIN 1.REF J.MOL.BIOL. V. 346 367 2005REFN ISSN 0022-2836PMID 15663951DOI 10.1016/J.JMB.2004.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2z7x TLR1 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]