Assessment of Structural Intolerance and Durability
General Structure Information 2ziv EME1 crystal structure of the mus81-eme1 complex 2.7Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Mapped Variants
General Structure Information 3dqv CUL5 structural insights into nedd8 activation of cullin-ring ligases: conformational control of conjugation 3.0Å AUTH D.M.DUDA,L.A.BORG,D.C.SCOTT,H.W.HUNT,M.HAMMEL,AUTH 2 B.A.SCHULMANTITL STRUCTURAL INSIGHTS INTO NEDD8 ACTIVATION OFTITL 2 CULLIN-RING LIGASES: CONFORMATIONAL CONTROL OFTITL 3 CONJUGATION.REF CELL(CAMBRIDGE,MASS.) V. 134 995 2008REFN ISSN 0092-8674PMID 18805092DOI 10.1016/J.CELL.2008.07.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ei4 DDB2 structure of the hsddb1-hsddb2 complex 3.3Å AUTH A.SCRIMA,R.KONICKOVA,B.K.CZYZEWSKI,Y.KAWASAKI,P.D.JEFFREY,AUTH 2 R.GROISMAN,Y.NAKATANI,S.IWAI,N.P.PAVLETICH,N.H.THOMATITL STRUCTURAL BASIS OF UV DNA-DAMAGE RECOGNITION BY THETITL 2 DDB1-DDB2 COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 135 1213 2008REFN ISSN 0092-8674PMID 19109893DOI 10.1016/J.CELL.2008.10.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 4drb FANCM the crystal structure of fancm bound mhf complex 2.63Å AUTH Y.TAO,C.JIN,X.LI,S.QI,L.CHU,L.NIU,X.YAO,M.TENGTITL THE STRUCTURE OF THE FANCM-MHF COMPLEX REVEALS PHYSICALTITL 2 FEATURES FOR FUNCTIONAL ASSEMBLYREF NAT COMMUN V. 3 782 2012REFN ESSN 2041-1723PMID 22510687DOI 10.1038/NCOMMS1779 Variant Set Distributions Mapped Variants
General Structure Information 2kuo APLF structure and identification of adp-ribose recognition motifs of aplf and role in the dna damage response -1.0Å AUTH G.Y.LI,R.D.MCCULLOCH,A.FENTON,M.CHEUNG,L.MENG,M.IKURA,AUTH 2 C.A.KOCHTITL STRUCTURE AND IDENTIFICATION OF ADP-RIBOSE RECOGNITIONTITL 2 MOTIFS OF APRATAXIN PNK-LIKE FACTOR (APLF) REQUIRED FOR THETITL 3 INTERACTION WITH SITES OF DNA DAMAGE RESPONSEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 4m6w FANCM crystal structure of the c-terminal segment of fancm in complex with faap24 2.9Å AUTH H.YANG,T.ZHANG,Y.TAO,F.WANG,L.TONG,J.DINGTITL STRUCTURAL INSIGHTS INTO THE FUNCTIONS OF THE FANCM-FAAP24TITL 2 COMPLEX IN DNA REPAIR.REF NUCLEIC ACIDS RES. V. 41 10573 2013REFN ISSN 0305-1048PMID 24003026DOI 10.1093/NAR/GKT788 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3hf1 RRM2B crystal structure of human p53r2 2.6Å AUTH P.SMITH,B.ZHOU,N.HO,Y.C.YUAN,L.SU,S.C.TSAI,Y.YENTITL 2.6 A X-RAY CRYSTAL STRUCTURE OF HUMAN P53R2, ATITL 2 P53-INDUCIBLE RIBONUCLEOTIDE REDUCTASE .REF BIOCHEMISTRY V. 48 11134 2009REFN ISSN 0006-2960PMID 19728742DOI 10.1021/BI9001425 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ndy APITD1 human mhf1-mhf2 dna complex 7.0Å AUTH Q.ZHAO,D.SARO,A.SACHPATZIDIS,T.R.SINGH,D.SCHLINGMAN,AUTH 2 X.F.ZHENG,A.MACK,M.S.TSAI,S.MOCHRIE,L.REGAN,A.R.MEETEI,AUTH 3 P.SUNG,Y.XIONGTITL THE MHF COMPLEX SENSES BRANCHED DNA BY BINDING A PAIR OFTITL 2 CROSSOVER DNA DUPLEXES.REF NAT COMMUN V. 5 2987 2014REFN ESSN 2041-1723PMID 24390579DOI 10.1038/NCOMMS3987 Variant Set Distributions Mapped Variants