Assessment of Structural Intolerance and Durability
General Structure Information 2vkc N4BP2 solution structure of the b3bp smr domain -1.0Å AUTH T.DIERCKS,E.AB,M.A.DANIELS,R.N.DE JONG,R.BESSELING,AUTH 2 R.KAPTEIN,G.E.FOLKERSTITL SOLUTION STRUCTURE AND CHARACTERIZATION OF THETITL 2 DNA- BINDING ACTIVITY OF THE B3BP-SMR DOMAIN.REF J.MOL.BIOL. V. 383 1156 2008REFN ISSN 0022-2836PMID 18804481DOI 10.1016/J.JMB.2008.09.005 Variant Set Distributions Mapped Variants
General Structure Information 4ndg APTX human aprataxin (aptx) bound to rna-dna and zn – adenosine vanadate transition state mimic complex 2.54Å AUTH P.TUMBALE,J.S.WILLIAMS,M.J.SCHELLENBERG,T.A.KUNKEL,AUTH 2 R.S.WILLIAMSTITL APRATAXIN RESOLVES ADENYLATED RNA-DNA JUNCTIONS TO MAINTAINTITL 2 GENOME INTEGRITY.REF NATURE V. 506 111 2013REFN ISSN 0028-0836PMID 24362567DOI 10.1038/NATURE12824 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3k9j SETMAR transposase domain of metnase 1.9Å AUTH K.D.GOODWIN,H.HE,T.IMASAKI,S.H.LEE,M.M.GEORGIADISTITL CRYSTAL STRUCTURE OF THE HUMAN HSMAR1-DERIVED TRANSPOSASETITL 2 DOMAIN IN THE DNA REPAIR ENZYME METNASE.REF BIOCHEMISTRY V. 49 5705 2010REFN ISSN 0006-2960PMID 20521842DOI 10.1021/BI100171X Variant Set Distributions Mapped Variants
General Structure Information 4b87 DCLRE1A crystal structure of human dna cross-link repair 1a 2.16Å AUTH C.K.ALLERSTON,G.BERRIDGE,E.P.CARPENTER,G.KOCHAN,T.KROJER,AUTH 2 P.MAHAJAN,M.VOLLMAR,W.W.YUE,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3i8e DDB1 crystal structure of ddb1 in complex with the h-box motif of wdr42a 3.4Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRAL HIJACKERSTITL 2 AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1 UBIQUITIN LIGASETITL 3 MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3i7p DCAF12 crystal structure of ddb1 in complex with the h-box motif of wdr40a 3.0Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRALTITL 2 HIJACKERS AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1TITL 3 UBIQUITIN LIGASE MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Mapped Variants
General Structure Information 3h8x ALKBH2 structure determination of dna methylation lesions n1-mea and n3-mec in duplex dna using a cross-linked host-guest system 1.95Å AUTH L.LU,C.YI,X.JIAN,G.ZHENG,C.HETITL STRUCTURE DETERMINATION OF DNA METHYLATION LESIONS N1-MEATITL 2 AND N3-MEC IN DUPLEX DNA USING A CROSS-LINKED PROTEIN-DNATITL 3 SYSTEM.REF NUCLEIC ACIDS RES. V. 38 4415 2010REFN ISSN 0305-1048PMID 20223766DOI 10.1093/NAR/GKQ129 […]
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2l1i HLTF nmr structure of the hltf hiran domain -1.0Å AUTH D.NECULAI,I.BEZSONOVA,J.WEIGELT,C.BOUNTRA,A.EDWARDS,AUTH 2 C.ARROWSMITH,S.DHE-PAGANONTITL NMR STRUCTURE OF THE HLTF HIRAN DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants