Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rje L3MBTL1 crystal structure of l3mbtl1 in complex with h4k20me2 (residues 17- 25), orthorhombic form ii 1.86Å AUTH J.MIN,A.ALLALI-HASSANI,N.NADY,C.QI,H.OUYANG,Y.LIU,AUTH 2 F.MACKENZIE,M.VEDADI,C.H.ARROWSMITHTITL L3MBTL1 RECOGNITION OF MONO- AND DIMETHYLATED HISTONES.REF NAT.STRUCT.MOL.BIOL. V. 14 1229 2007REFN ISSN 1545-9993PMID 18026117DOI 10.1038/NSMB1340 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z6e DAAM1 crystal structure of human daam1 fh2 2.8Å AUTH M.YAMASHITA,T.HIGASHI,S.SUETSUGU,Y.SATO,T.IKEDA,AUTH 2 R.SHIRAKAWA,T.KITA,T.TAKENAWA,H.HORIUCHI,S.FUKAI,AUTH 3 O.NUREKITITL CRYSTAL STRUCTURE OF HUMAN DAAM1 FORMIN HOMOLOGY 2TITL 2 DOMAINREF GENES CELLS V. 12 1255 2007REFN ISSN 1356-9597PMID 17986009DOI 10.1111/J.1365-2443.2007.01132.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3enp TPRKB crystal structure of human cgi121 2.48Å AUTH D.Y.MAO,D.NECULAI,M.DOWNEY,S.ORLICKY,Y.Z.HAFFANI,AUTH 2 D.F.CECCARELLI,J.S.HO,R.K.SZILARD,W.ZHANG,C.S.HO,L.WAN,AUTH 3 C.FARES,S.RUMPEL,I.KURINOV,C.H.ARROWSMITH,D.DUROCHER,AUTH 4 F.SICHERITITL ATOMIC STRUCTURE OF THE KEOPS COMPLEX: AN ANCIENT PROTEINTITL 2 KINASE-CONTAINING MOLECULAR MACHINE.REF MOL.CELL V. 32 259 2008REFN ISSN 1097-2765PMID 18951093DOI 10.1016/J.MOLCEL.2008.10.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2pv0 DNMT3L dna methyltransferase 3 like protein (dnmt3l) 3.3Å AUTH S.K.OOI,C.QIU,E.BERNSTEIN,K.LI,D.JIA,Z.YANG,AUTH 2 H.ERDJUMENT-BROMAGE,P.TEMPST,S.P.LIN,C.D.ALLIS,AUTH 3 X.CHENG,T.H.BESTORTITL DNMT3L CONNECTS UNMETHYLATED LYSINE 4 OF HISTONETITL 2 H3 TO DE NOVO METHYLATION OF DNA.REF NATURE V. 448 714 2007REFN ISSN 0028-0836PMID 17687327DOI 10.1038/NATURE05987 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2xah RCOR1 crystal structure of lsd1-corest in complex with (+)- trans-2-phenylcyclopropyl-1-amine 3.1Å AUTH C.BINDA,S.VALENTE,M.ROMANENGHI,S.PILOTTO,R.CIRILLI,AUTH 2 A.KARYTINOS,G.CIOSSANI,O.A.BOTRUGNO,F.FORNERIS,AUTH 3 M.TARDUGNO,D.E.EDMONDSON,S.MINUCCI,A.MATTEVI,A.MAITITL BIOCHEMICAL, STRUCTURAL, AND BIOLOGICAL EVALUATIONTITL 2 OF TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OFTITL 3 HISTONE DEMETHYLASES LSD1 AND LSD2.REF J.AM.CHEM.SOC. V. 132 6827 2010REFN ISSN 0002-7863PMID 20415477DOI 10.1021/JA101557K Variant Set Distributions Mapped Variants
General Structure Information 1zv4 RGS17 structure of the regulator of g-protein signaling 17 (rgsz2) 2.4Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 3vro CBLC crystal structure of the tyrosine kinase binding domain of cbl-c in complex with phospho-src peptide 1.8Å AUTH K.TAKESHITA,T.TEZUKA,Y.ISOZAKI,E.YAMASHITA,M.SUZUKI,M.KIM,AUTH 2 Y.YAMANASHI,T.YAMAMOTO,A.NAKAGAWATITL STRUCTURAL FLEXIBILITY REGULATES PHOSPHOPEPTIDE-BINDINGTITL 2 ACTIVITY OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C.REF J.BIOCHEM. V. 152 487 2012REFN ISSN 0021-924XPMID 22888118DOI 10.1093/JB/MVS085 Variant Set Distributions Mapped Variants
General Structure Information 2xd7 H2AFY2 crystal structure of the macro domain of human core histone h2a 2.09Å AUTH M.VOLLMAR,C.PHILLIPPS,E.P.CARPENTER,J.R.C.MUNIZ,AUTH 2 T.KROJER,E.UGOCHUKWU,F.VON DELFT,C.BOUNTRA,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,O.GILEADITITL CRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMANTITL 2 CORE HISTONE H2AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants