General Structure Information
| PDB ID | 2pv0 |
| HGNC Gene Label(s) | DNMT3L |
| Structure Name | dna methyltransferase 3 like protein (dnmt3l) |
| Resolution | 3.3Å |
| Reference | AUTH S.K.OOI,C.QIU,E.BERNSTEIN,K.LI,D.JIA,Z.YANG,AUTH 2 H.ERDJUMENT-BROMAGE,P.TEMPST,S.P.LIN,C.D.ALLIS,AUTH 3 X.CHENG,T.H.BESTORTITL DNMT3L CONNECTS UNMETHYLATED LYSINE 4 OF HISTONETITL 2 H3 TO DE NOVO METHYLATION OF DNA.REF NATURE V. 448 714 2007REFN ISSN 0028-0836PMID 17687327DOI 10.1038/NATURE05987 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 347 |
| Number Of SNVs | 102 |
| Number Of Permutations | 22909 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.221 |
| p-value | 0.16 |
COSMIC
| Number Of Residues | 347 |
| Number Of SNVs | 4 |
| Number Of Permutations | 411 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.411 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 102 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.134 |
| p-value | 0.589 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
