Assessment of Structural Intolerance and Durability
General Structure Information 3n5u PPP1CA crystal structure of an rb c-terminal peptide bound to the catalytic subunit of pp1 3.2Å AUTH A.HIRSCHI,M.CECCHINI,R.C.STEINHARDT,M.R.SCHAMBER,F.A.DICK,AUTH 2 S.M.RUBINTITL AN OVERLAPPING KINASE AND PHOSPHATASE DOCKING SITE REGULATESTITL 2 ACTIVITY OF THE RETINOBLASTOMA PROTEIN.REF NAT.STRUCT.MOL.BIOL. V. 17 1051 2010REFN ISSN 1545-9993PMID 20694007DOI 10.1038/NSMB.1868 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3dju BTG2 crystal structure of human btg2 2.26Å AUTH X.YANG,M.MORITA,H.WANG,T.SUZUKI,W.YANG,Y.LUO,AUTH 2 C.ZHAO,Y.YU,M.BARTLAM,T.YAMAMOTO,Z.RAOTITL CRYSTAL STRUCTURES OF HUMAN BTG2 AND MOUSE TIS21TITL 2 INVOLVED IN SUPPRESSION OF CAF1 DEADENYLASETITL 3 ACTIVITYREF NUCLEIC ACIDS RES. V. 36 6872 2008REFN ISSN 0305-1048PMID 18974182DOI 10.1093/NAR/GKN825 Variant Set Distributions Mapped Variants
General Structure Information 1pq6 NR1H2 human lxr beta hormone receptor / gw3965 complex 2.4Å AUTH M.FARNEGARDH,T.BONN,S.SUN,J.LJUNGGREN,H.AHOLA,A.WILHELMSSON,AUTH 2 J.-A.GUSTAFSSON,M.CARLQUISTTITL THE THREE-DIMENSIONAL STRUCTURE OF THE LIVER X RECEPTOR BETATITL 2 REVEALS A FLEXIBLE LIGAND-BINDING POCKET THAT CANTITL 3 ACCOMMODATE FUNDAMENTALLY DIFFERENT LIGANDS.REF J.BIOL.CHEM. V. 278 38821 2003REFN ISSN 0021-9258PMID 12819202DOI 10.1074/JBC.M304842200 Variant Set Distributions Mapped Variants
General Structure Information 2bid BID human pro-apoptotic protein bid -1.0Å AUTH J.J.CHOU,H.LI,G.S.SALVESEN,J.YUAN,G.WAGNERTITL SOLUTION STRUCTURE OF BID, AN INTRACELLULARTITL 2 AMPLIFIER OF APOPTOTIC SIGNALING.REF CELL(CAMBRIDGE,MASS.) V. 96 615 1999REFN ISSN 0092-8674PMID 10089877DOI 10.1016/S0092-8674(00)80572-3 Variant Set Distributions Mapped Variants
General Structure Information 2kqs SUMO1 phosphorylation of sumo-interacting motif by ck2 enhances daxx sumo binding activity -1.0Å AUTH C.C.CHANG,M.T.NAIK,Y.S.HUANG,J.C.JENG,P.H.LIAO,H.Y.KUO,AUTH 2 C.C.HO,Y.L.HSIEH,C.H.LIN,N.J.HUANG,N.M.NAIK,C.C.KUNG,AUTH 3 S.Y.LIN,R.H.CHEN,K.S.CHANG,T.H.HUANG,H.M.SHIHTITL STRUCTURAL AND FUNCTIONAL ROLES OF DAXX SIM PHOSPHORYLATIONTITL 2 IN SUMO PARALOG-SELECTIVE BINDING AND APOPTOSIS MODULATION.REF MOL.CELL V. 42 62 2011REFN ISSN 1097-2765PMID 21474068DOI 10.1016/J.MOLCEL.2011.02.022 Variant Set Distributions Mapped Variants
General Structure Information 2kwo HIST4H4 solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4J solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4F solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4H solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4C solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]