Assessment of Structural Intolerance and Durability
General Structure Information 2ce8 TLE1 an eh1 peptide bound to the groucho-tle wd40 domain. 2.03Å AUTH B.H.JENNINGS,L.M.PICKLES,S.M.WAINWRIGHT,S.M.ROE,L.H.PEARL,AUTH 2 D.ISH-HOROWICZTITL MOLECULAR RECOGNITION OF TRANSCRIPTIONAL REPRESSOR MOTIFSTITL 2 BY THE WD DOMAIN OF THE GROUCHO/TLE COREPRESSOR.REF MOL.CELL V. 22 645 2006REFN ISSN 1097-2765PMID 16762837DOI 10.1016/J.MOLCEL.2006.04.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3dm1 CBX3 crystal structure of the complex of human chromobox homolog 3 (cbx3) with peptide 2.4Å AUTH J.RUAN,H.OUYANG,M.F.AMAYA,M.RAVICHANDRAN,P.LOPPNAU,J.MIN,AUTH 2 J.ZANGTITL STRUCTURAL BASIS OF THE CHROMODOMAIN OF CBX3 BOUND TOTITL 2 METHYLATED PEPTIDES FROM HISTONE H1 AND G9A.REF PLOS ONE V. 7 35376 2012REFN ESSN 1932-6203PMID 22514736DOI 10.1371/JOURNAL.PONE.0035376 Variant Set Distributions Mapped Variants
General Structure Information 1gzh TP53BP1 crystal structure of the brct domains of human 53bp1 bound to the p53 tumor supressor 2.6Å AUTH D.J.DERBYSHIRE,B.P.BASU,L.SERPELL,W.JOO,T.DATE,AUTH 2 K.IWABUCHI,A.J.DOHERTYTITL CRYSTAL STRUCTURE OF HUMAN 53BP1 BRCT DOMAINSTITL 2 BOUND TO P53 TUMOUR SUPPRESSORREF EMBO J. V. 21 3863 2002REFN ISSN 0261-4189PMID 12110597DOI 10.1093/EMBOJ/CDF383 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3h7h SUPT4H1 crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273) 1.55Å AUTH S.WENZEL,B.M.MARTINS,P.ROSCH,B.M.WOHRLTITL CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION ELONGATIONTITL 2 FACTOR DSIF HSPT4 SUBUNIT IN COMPLEX WITH THE HSPT5TITL 3 DIMERIZATION INTERFACEREF BIOCHEM.J. V. 425 373 2010REFN ISSN 0264-6021PMID 19860741DOI 10.1042/BJ20091422 Variant Set Distributions Mapped Variants
General Structure Information 1j1e TNNC1 crystal structure of the 52kda domain of human cardiac troponin in the ca2+ saturated form 3.3Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1vol GTF2B tfiib (human core domain)/tbp (a.thaliana)/tata element ternary complex 2.7Å AUTH D.B.NIKOLOV,H.CHEN,E.D.HALAY,A.A.USHEVA,K.HISATAKE,AUTH 2 D.K.LEE,R.G.ROEDER,S.K.BURLEYTITL CRYSTAL STRUCTURE OF A TFIIB-TBP-TATA-ELEMENTTITL 2 TERNARY COMPLEX.REF NATURE V. 377 119 1995REFN ISSN 0028-0836PMID 7675079DOI 10.1038/377119A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4js0 CDC42 complex of cdc42 with the crib-pr domain of irsp53 1.9Å AUTH D.J.KAST,C.YANG,A.DISANZA,M.BOCZKOWSKA,Y.MADASU,G.SCITA,AUTH 2 T.SVITKINA,R.DOMINGUEZTITL MECHANISM OF IRSP53 INHIBITION AND COMBINATORIAL ACTIVATIONTITL 2 BY CDC42 AND DOWNSTREAM EFFECTORS.REF NAT.STRUCT.MOL.BIOL. V. 21 413 2014REFN ISSN 1545-9993PMID 24584464DOI 10.1038/NSMB.2781 Variant Set Distributions Mapped Variants
General Structure Information 2e8p ELF3 solution structure of the n-terminal sam-domain of e74-like factor 3 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL SAM-DOMAIN OFTITL 2 E74-LIKE FACTOR 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vqv HDAC4 structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor 3.3Å AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID […]
General Structure Information 2x4x BRPF1 molecular basis of histone h3k36me3 recognition by the pwwp domain of brpf1. 1.85Å AUTH A.VEZZOLI,N.BONADIES,M.D.ALLEN,S.M.V.FREUND,AUTH 2 C.M.SANTIVERI,B.KVINLAUG,B.J.P.HUNTLY,B.GOTTGENS,AUTH 3 M.BYCROFTTITL MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BYTITL 2 THE PWWP DOMAIN OF BRPF1.REF NAT.STRUCT.MOL.BIOL. V. 17 617 2010REFN ISSN 1545-9993PMID 20400950DOI 10.1038/NSMB.1797 Variant Set Distributions Mapped Variants