Assessment of Structural Intolerance and Durability
General Structure Information 4hsa IL17RA structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 2nms CD300LF the crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells irem-1 2.6Å AUTH J.A.MARQUEZ,E.GALFRE,F.DUPEUX,D.FLOT,O.MORAN,AUTH 2 N.DIMASITITL THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAINTITL 2 OF THE INHIBITOR RECEPTOR EXPRESSED ON MYELOIDTITL 3 CELLS IREM-1.REF J.MOL.BIOL. V. 367 310 2007REFN ISSN 0022-2836PMID 17275839DOI 10.1016/J.JMB.2007.01.011 Variant Set […]
General Structure Information 3og4 IFNLR1 the crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p21212 2.16Å AUTH Z.J.MIKNIS,E.MAGRACHEVA,W.LI,A.ZDANOV,S.V.KOTENKO,A.WLODAWERTITL CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN INTERFERON-LAMBDA1TITL 2 WITH ITS HIGH AFFINITY RECEPTOR INTERFERON-LAMBDAR1.REF J.MOL.BIOL. V. 404 650 2010REFN ISSN 0022-2836PMID 20934432DOI 10.1016/J.JMB.2010.09.068 Variant Set Distributions Ripley’s K […]
General Structure Information 1wfv MAGI2 solution structure of the fifth pdz domain of human membrane associated guanylate kinase inverted-2 (kiaa0705 protein) -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH PDZ DOMAIN OFTITL 2 HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASETITL 3 INVERTED-2 (KIAA0705 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dgc IL22RA1 structure of il-22/il-22r1 2.5Å AUTH B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL STRUCTURE OF IL-22 BOUND TO ITS HIGH-AFFINITY IL-22R1 CHAIN.REF STRUCTURE V. 16 1333 2008REFN ISSN 0969-2126PMID 18599299DOI 10.1016/J.STR.2008.06.005 Variant Set Distributions Mapped Variants
General Structure Information 4m7h FIBCD1 crystal structure of tetrameric fibrinogen-like recognition domain of fibcd1 2.0Å AUTH A.K.SHRIVE,J.B.MOELLER,I.BURNS,J.M.PATERSON,A.J.SHAW,AUTH 2 A.SCHLOSSER,G.L.SORENSEN,T.J.GREENHOUGH,U.HOLMSKOVTITL CRYSTAL STRUCTURE OF THE TETRAMERIC FIBRINOGEN-LIKETITL 2 RECOGNITION DOMAIN OF FIBRINOGEN C DOMAIN CONTAINING 1TITL 3 (FIBCD1) PROTEIN.REF J.BIOL.CHEM. V. 289 2880 2014REFN ISSN 0021-9258PMID 24293368DOI 10.1074/JBC.M113.520577 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 2frg TREML1 structure of the immunoglobulin-like domain of human tlt-1 1.19Å AUTH J.L.GATTIS,A.V.WASHINGTON,M.M.CHISHOLM,L.QUIGLEY,AUTH 2 A.SZYK,D.W.MCVICAR,J.LUBKOWSKITITL THE STRUCTURE OF THE EXTRACELLULAR DOMAIN OFTITL 2 TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLSTITL 3 LIKE TRANSCRIPT-1 AND EVIDENCE FOR A NATURALLYTITL 4 OCCURRING SOLUBLE FRAGMENT.REF J.BIOL.CHEM. V. 281 13396 2006REFN ISSN 0021-9258PMID 16505478DOI 10.1074/JBC.M600489200 Variant Set […]
General Structure Information 3wbp CLEC4C crystal structure of carbohydrate recognition domain of blood dendritic cell antigen-2 (bdca2) lectin (crystal form-1) 1.8Å AUTH M.NAGAE,A.IKEDA,Y.KITAGO,N.MATSUMOTO,K.YAMAMOTO,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF CARBOHYDRATE RECOGNITION DOMAIN OFTITL 2 BLOOD DENDRITIC CELL ANTIGEN-2 (BDCA2) REVEAL A COMMONTITL 3 DOMAIN-SWAPPED DIMERREF PROTEINS 2013REFN ESSN 1097-0134PMID 24425442DOI 10.1002/PROT.24504 Variant Set Distributions Ripley’s K Analysis Plots […]