Assessment of Structural Intolerance and Durability
General Structure Information 2jng CUL7 solution structure of the cul7-cph domain from homo sapiens; northeast structural genomics consortium target ht1. -1.0Å AUTH L.KAUSTOV,J.LUKIN,A.LEMAK,S.DUAN,M.HO,R.DOHERTY,AUTH 2 L.Z.PENN,C.H.ARROWSMITHTITL THE CONSERVED CPH DOMAINS OF CUL7 AND PARC ARETITL 2 PROTEIN-PROTEIN INTERACTION MODULES THAT BIND THETITL 3 TETRAMERIZATION DOMAIN OF P53REF J.BIOL.CHEM. V. 282 11300 2007REFN ISSN 0021-9258PMID 17298945DOI 10.1074/JBC.M611297200 […]
General Structure Information 2l5u CHD4 structure of the first phd finger (phd1) from chd4 (mi2b) -1.0Å AUTH R.E.MANSFIELD,C.A.MUSSELMAN,A.H.KWAN,S.S.OLIVER,A.L.GARSKE,AUTH 2 F.DAVRAZOU,J.M.DENU,T.G.KUTATELADZE,J.P.MACKAYTITL PLANT HOMEODOMAIN (PHD) FINGERS OF CHD4 ARE HISTONETITL 2 H3-BINDING MODULES WITH PREFERENCE FOR UNMODIFIED H3K4 ANDTITL 3 METHYLATED H3K9REF J.BIOL.CHEM. V. 286 11779 2011REFN ISSN 0021-9258PMID 21278251DOI 10.1074/JBC.M110.208207 Variant Set Distributions Mapped Variants
General Structure Information 2d8z FHL2 solution structure of the third lim domain of four and a half lim domains protein 2 (fhl-2) -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD LIM DOMAIN OF FOURTITL 2 AND A HALF LIM DOMAINS PROTEIN 2 (FHL-2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2mbg RALBP1 rlip76 (gap-gbd) -1.0Å AUTH K.V.RAJASEKAR,L.J.CAMPBELL,D.NIETLISPACH,D.OWEN,H.R.MOTTTITL THE STRUCTURE OF THE RLIP76 RHOGAP-RAL BINDING DOMAIN DYAD:TITL 2 FIXED POSITION OF THE DOMAINS LEADS TO DUAL ENGAGEMENT OFTITL 3 SMALL G PROTEINS AT THE MEMBRANE.REF STRUCTURE V. 21 2131 2013REFN ISSN 0969-2126PMID 24207123DOI 10.1016/J.STR.2013.09.007 Variant Set Distributions Mapped Variants
General Structure Information 1s1c ROCK1 crystal structure of the complex between the human rhoa and rho-binding domain of human rocki 2.6Å AUTH R.DVORSKY,L.BLUMENSTEIN,I.R.VETTER,M.R.AHMADIANTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF ROCKITITL 2 WITH THE SWITCH REGIONS OF RHOA.REF J.BIOL.CHEM. V. 279 7098 2004REFN ISSN 0021-9258PMID 14660612DOI 10.1074/JBC.M311911200 Variant Set Distributions Mapped Variants
General Structure Information 3g4h RGN crystal structure of human senescence marker protein-30 (zinc bound) 1.92Å AUTH S.CHAKRABORTI,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN SENESCENCE MARKER PROTEIN 30:TITL 2 INSIGHTS LINKING STRUCTURAL, ENZYMATIC, AND PHYSIOLOGICALTITL 3 FUNCTIONS .REF BIOCHEMISTRY V. 49 3436 2010REFN ISSN 0006-2960PMID 20329768DOI 10.1021/BI9022297 Variant Set Distributions Mapped Variants
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2e7c MYBPC2 solution structure of the 6th ig-like domain from human myosin-binding protein c, fast-type -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 6TH IG-LIKE DOMAIN FROMTITL 2 HUMAN MYOSIN-BINDING PROTEIN C, FAST-TYPEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uap PCOLCE nmr structure of the ntr domain from human pcolce1 -1.0Å AUTH E.LIEPINSH,L.BANYAI,G.PINTACUDA,M.TREXLER,L.PATTHY,AUTH 2 G.OTTINGTITL NMR STRUCTURE OF THE NETRIN-LIKE DOMAIN (NTR) OFTITL 2 HUMAN TYPE I PROCOLLAGEN C-PROTEINASE ENHANCERTITL 3 DEFINES STRUCTURAL CONSENSUS OF NTR DOMAINS ANDTITL 4 ASSESSES POTENTIAL PROTEINASE INHIBITORY ACTIVITYTITL 5 AND LIGAND BINDING.REF J.BIOL.CHEM. V. 278 […]