Assessment of Structural Intolerance and Durability
General Structure Information 4has SNX27 crystal structure of px domain of human sorting nexin snx27 1.74Å AUTH D.S.FROESE,T.KROJER,C.STRAIN-DAMERELL,C.ALLERSTON,W.KIYANI,AUTH 2 N.BURGESS-BROWN,F.VON DELFT,C.ARROWSMITH,C.BOUNTRA,AUTH 3 A.EDWARDS,W.W.YUE,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PX DOMAIN OF HUMAN SORTING NEXIN SNX27REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3m66 MTERFD1 crystal structure of human mitochondrial transcription termination factor 3 1.6Å AUTH H.SPAHR,T.SAMUELSSON,B.M.HALLBERG,C.M.GUSTAFSSONTITL STRUCTURE OF MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTORTITL 2 3 REVEALS A NOVEL NUCLEIC ACID-BINDING DOMAIN.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 397 386 2010REFN ISSN 0006-291XPMID 20430012DOI 10.1016/J.BBRC.2010.04.130 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yuj UFD1L solution structure of human ubiquitin fusion degradation protein 1 homolog ufd1 -1.0Å AUTH K.SAITO,T.TOMIZAWA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF HUMAN UBIQUITIN FUSIONTITL 2 DEGRADATION PROTEIN 1 HOMOLOG UFD1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x5f NEO1 the solution structure of the first fibronectin type iii domain of human neogenin -1.0Å AUTH N.TOCHIO,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE FIRST FIBRONECTINTITL 2 TYPE III DOMAIN OF HUMAN NEOGENINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pa1 PDLIM2 structure of the pdz domain of human pdlim2 bound to a c-terminal extension from human beta-tropomyosin 1.7Å AUTH J.UPPENBERG,L.SHRESTHA,J.ELKINS,N.BURGESS-BROWN,E.SALAH,AUTH 2 G.BUNKOCZI,E.PAPAGRIGORIOU,A.C.W.PIKE,A.P.TURNBULL,AUTH 3 E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 4 A.EDWARDS,M.SUNDSTROM,D.A.DOYLETITL STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM2 BOUND TO ATITL 2 C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2erx DIRAS2 crystal structure of diras2 in complex with gdp and inorganic phosphate 1.65Å AUTH E.PAPAGRIGORIOU,X.YANG,J.ELKINS,F.E.NIESEN,AUTH 2 N.BURGESS,E.SALAH,O.FEDOROV,L.J.BALL,F.VON DELFT,AUTH 3 M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,J.WEIGELT,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF DIRAS2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f52 GLMN structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 3ddt TRIM63 crystal structure of the b2 box from murf1 in dimeric state 1.9Å AUTH M.MROSEK,S.MEIER,Z.UCURUM-FOTIADIS,E.VON CASTELMUR,AUTH 2 E.HEDBOM,A.LUSTIG,S.GRZESIEK,D.LABEIT,S.LABEIT,AUTH 3 O.MAYANSTITL STRUCTURAL ANALYSIS OF B-BOX 2 FROM MURF1:TITL 2 IDENTIFICATION OF A NOVEL SELF-ASSOCIATION PATTERNTITL 3 IN A RING-LIKE FOLDREF BIOCHEMISTRY V. 47 10722 2008REFN ISSN 0006-2960PMID 18795805DOI 10.1021/BI800733Z Variant Set Distributions […]
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2gw6 TSEN15 nmr structure of the human trna endonuclease sen15 subunit -1.0Å AUTH J.SONG,J.L.MARKLEYTITL THREE-DIMENSIONAL STRUCTURE DETERMINED FOR ATITL 2 SUBUNIT OF HUMAN TRNA SPLICING ENDONUCLEASETITL 3 (SEN15) REVEALS A NOVEL DIMERIC FOLD.REF J.MOL.BIOL. V. 366 155 2007REFN ISSN 0022-2836PMID 17166513DOI 10.1016/J.JMB.2006.11.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]