Assessment of Structural Intolerance and Durability
General Structure Information 1x6f ZNF462 solution structures of the c2h2 type zinc finger domain of human zinc finger protein 462 -1.0Å AUTH M.SATO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 462REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2eax PGLYRP4 crystal structure of human pgrp-ibetac in complex with glycosamyl muramyl pentapeptide 2.1Å AUTH S.CHO,Q.WANG,C.P.SWAMINATHAN,D.HESEK,M.LEE,G.J.BOONS,AUTH 2 S.MOBASHERY,R.A.MARIUZZATITL STRUCTURAL INSIGHTS INTO THE BACTERICIDAL MECHANISM OF HUMANTITL 2 PEPTIDOGLYCAN RECOGNITION PROTEINSREF PROC.NATL.ACAD.SCI.USA V. 104 8761 2007REFN ISSN 0027-8424PMID 17502600DOI 10.1073/PNAS.0701453104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1shz ARHGEF1 crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera 2.85Å AUTH Z.CHEN,W.D.SINGER,P.C.STERNWEIS,S.R.SPRANGTITL STRUCTURE OF THE P115RHOGEF RGRGSTITL 2 DOMAIN-GALPHA13/I1 CHIMERA COMPLEX SUGGESTSTITL 3 CONVERGENT EVOLUTION OF A GTPASE ACTIVATOR.REF NAT.STRUCT.MOL.BIOL. V. 12 191 2005REFN ISSN 1545-9993PMID 15665872DOI 10.1038/NSMB888 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 1wf6 TOPBP1 the third brca1 c-terminus (brct) domain of similar to s.pombe rad4+/cut5+ product -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE THIRD BRCA1 C-TERMINUS (BRCT) DOMAIN OFTITL 2 SIMILAR TO S.POMBE RAD4+/CUT5+ PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l80 USP13 solution structure of the zinc finger domain of usp13 -1.0Å AUTH Y.ZHANG,A.SONG,C.ZHOU,Z.ZHOU,H.HUTITL BIOCHEMICAL CHARACTERIZATION OF THE UBIQUITIN RECEPTORS INTITL 2 USP13 REVEALS DIFFERENT CATALYTIC ACTIVATION OFTITL 3 DEUBIQUITINATION FROM ITS ANALOGUE USP5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x5g NEO1 the solution structure of the second fibronectin type iii domain of human neogenin -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE SECOND FIBRONECTINTITL 2 TYPE III DOMAIN OF HUMAN NEOGENINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lor TMEM141 backbone structure of human membrane protein tmem141 -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2fue PMM1 human alpha-phosphomannomutase 1 with d-mannose 1-phosphate and mg2+ cofactor bound 1.75Å AUTH N.R.SILVAGGI,C.ZHANG,Z.LU,J.DAI,D.DUNAWAY-MARIANO,K.N.ALLENTITL THE X-RAY CRYSTAL STRUCTURES OF HUMANTITL 2 ALPHA-PHOSPHOMANNOMUTASE 1 REVEAL THE STRUCTURAL BASIS OFTITL 3 CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1A.REF J.BIOL.CHEM. V. 281 14918 2006REFN ISSN 0021-9258PMID 16540464DOI 10.1074/JBC.M601505200 Variant Set Distributions Mapped Variants
General Structure Information 4fq3 TNPO1 crystal structure of transportin/fus-nls 3.0Å AUTH W.GONG,C.NIU,M.JIA,F.GAOTITL CRYSTAL STRUCTURE OF TRANSPORTIN/FUS-NLSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants