General Structure Information
| PDB ID | 1shz |
| HGNC Gene Label(s) | ARHGEF1 |
| Structure Name | crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera |
| Resolution | 2.85Å |
| Reference | AUTH Z.CHEN,W.D.SINGER,P.C.STERNWEIS,S.R.SPRANGTITL STRUCTURE OF THE P115RHOGEF RGRGSTITL 2 DOMAIN-GALPHA13/I1 CHIMERA COMPLEX SUGGESTSTITL 3 CONVERGENT EVOLUTION OF A GTPASE ACTIVATOR.REF NAT.STRUCT.MOL.BIOL. V. 12 191 2005REFN ISSN 1545-9993PMID 15665872DOI 10.1038/NSMB888 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 188 |
| Number Of SNVs | 43 |
| Number Of Permutations | 12631 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.183 |
| p-value | 0.395 |
COSMIC
| Number Of Residues | 188 |
| Number Of SNVs | 5 |
| Number Of Permutations | 3084 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.1 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.063 |
| p-value | 0.855 |