Assessment of Structural Intolerance and Durability
General Structure Information 2x6u TBX5 crystal structure of human tbx5 in the dna-free form 1.9Å AUTH C.U.STIRNIMANN,D.PTCHELKINE,C.GRIMM,C.W.MULLERTITL STRUCTURAL BASIS OF TBX5-DNA RECOGNITION: THE T-TITL 2 BOX DOMAIN IN ITS DNA-BOUND AND -UNBOUND FORM.REF J.MOL.BIOL. V. 400 71 2010REFN ISSN 0022-2836PMID 20450920DOI 10.1016/J.JMB.2010.04.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3vtw MAP1LC3B crystal structure of t7-tagged optineurin lir-fused human lc3b_2-119 2.52Å AUTH V.V.ROGOV,H.SUZUKI,E.FISKIN,P.WILD,A.KNISS,A.ROZENKNOP,AUTH 2 R.KATO,M.KAWASAKI,D.G.MCEWAN,F.LOHR,P.GUNTERT,I.DIKIC,AUTH 3 S.WAKATSUKI,V.DOTSCHTITL STRUCTURAL BASIS FOR PHOSPHORYLATION-TRIGGERED AUTOPHAGICTITL 2 CLEARANCE OF SALMONELLAREF BIOCHEM.J. V. 454 459 2013REFN ISSN 0264-6021PMID 23805866DOI 10.1042/BJ20121907 Variant Set Distributions Mapped Variants
General Structure Information 1×52 PELO solution structures of the c-terminal domain of the human pelota homolog (cgi-17) -1.0Å AUTH N.NAMEKI,M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C-TERMINAL DOMAIN OFTITL 2 THE HUMAN PELOTA HOMOLOG (CGI-17)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2k8p SOST characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of wnt-mediated bone formation -1.0Å AUTH V.VEVERKA,A.J.HENRY,P.M.SLOCOMBE,A.VENTOM,B.MULLOY,AUTH 2 F.W.MUSKETT,M.MUZYLAK,K.GREENSLADE,A.MOORE,L.ZHANG,AUTH 3 J.GONG,X.QIAN,C.PASZTY,R.J.TAYLOR,M.K.ROBINSON,AUTH 4 M.D.CARRTITL CHARACTERIZATION OF THE STRUCTURAL FEATURES ANDTITL 2 INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTOTITL 3 A KEY REGULATOR OF WNT-MEDIATED BONE FORMATIONREF J.BIOL.CHEM. […]
General Structure Information 2mkf UIMC1 solution structure of the e81 deletion mutant of the tandem uims of rap80 -1.0Å AUTH ANAMIKA,C.J.MARKIN,M.K.ROUT,L.SPYRACOPOULOSTITL MOLECULAR BASIS FOR IMPAIRED DNA DAMAGE RESPONSE FUNCTIONTITL 2 ASSOCIATED WITH THE RAP80 DELTA E81 DEFECT.REF J.BIOL.CHEM. V. 289 12852 2014REFN ISSN 0021-9258PMID 24627472DOI 10.1074/JBC.M113.538280 Variant Set Distributions Mapped Variants
General Structure Information 2z0v SH3GL3 crystal structure of bar domain of endophilin-iii 2.49Å AUTH K.MURAYAMA,M.KATO-MURAYAMA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF BAR DOMAIN OF ENDOPHILIN-IIIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kpk MAGI1 magi-1 pdz1 -1.0Å AUTH S.CHARBONNIER,Y.NOMINE,J.RAMIREZ,K.LUCK,A.CHAPELLE,AUTH 2 R.H.STOTE,G.TRAVE,B.KIEFFER,R.A.ATKINSONTITL THE STRUCTURAL AND DYNAMIC RESPONSE OF MAGI-1 PDZ1 WITHTITL 2 NON-CANONICAL DOMAIN BOUNDARIES TO BINDING OF HUMANTITL 3 PAPILLOMAVIRUS (HPV) E6REF J.MOL.BIOL. 2011REFN ESSN 1089-8638PMID 21238461DOI 10.1016/J.JMB.2011.01.015 Variant Set Distributions Mapped Variants
General Structure Information 4lhy RAB3IP crystal structure of gdp-bound rab8:rabin8 3.1Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 2×47 MACROD1 crystal structure of human macrod1 1.7Å AUTH D.CHEN,M.VOLLMAR,M.N.ROSSI,C.PHILLIPS,R.KRAEHENBUEHL,AUTH 2 D.SLADE,P.V.MEHROTRA,F.VON DELFT,S.K.CROSTHWAITE,O.GILEADI,AUTH 3 J.M.DENU,I.AHELTITL IDENTIFICATION OF MACRO DOMAIN PROTEINS AS NOVEL O-TITL 2 ACETYL-ADP-RIBOSE DEACETYLASES.REF J.BIOL.CHEM. V. 286 13261 2011REFN ISSN 0021-9258PMID 21257746DOI 10.1074/JBC.M110.206771 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4jvh QKI structure of the star domain of quaking protein in complex with rna 3.5Å AUTH M.TEPLOVA,M.HAFNER,D.TEPLOV,K.ESSIG,T.TUSCHL,D.J.PATELTITL STRUCTURE-FUNCTION STUDIES OF STAR FAMILY QUAKING PROTEINSTITL 2 BOUND TO THEIR IN VIVO RNA TARGET SITES.REF GENES DEV. V. 27 928 2013REFN ISSN 0890-9369PMID 23630077DOI 10.1101/GAD.216531.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]