General Structure Information
| PDB ID | 2k8p |
| HGNC Gene Label(s) | SOST |
| Structure Name | characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of wnt-mediated bone formation |
| Resolution | -1.0Å |
| Reference | AUTH V.VEVERKA,A.J.HENRY,P.M.SLOCOMBE,A.VENTOM,B.MULLOY,AUTH 2 F.W.MUSKETT,M.MUZYLAK,K.GREENSLADE,A.MOORE,L.ZHANG,AUTH 3 J.GONG,X.QIAN,C.PASZTY,R.J.TAYLOR,M.K.ROBINSON,AUTH 4 M.D.CARRTITL CHARACTERIZATION OF THE STRUCTURAL FEATURES ANDTITL 2 INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTOTITL 3 A KEY REGULATOR OF WNT-MEDIATED BONE FORMATIONREF J.BIOL.CHEM. V. 284 10890 2009REFN ISSN 0021-9258PMID 19208630DOI 10.1074/JBC.M807994200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 189 |
| Number Of SNVs | 49 |
| Number Of Permutations | 84995 |
| Optimal Distance Threshold | 50.0 |
| K Statistic | 0.307 |
| p-value | 0.036 |
COSMIC
| Number Of Residues | 189 |
| Number Of SNVs | 5 |
| Number Of Permutations | 5828 |
| Optimal Distance Threshold | 57.0 |
| K Statistic | 0.1 |
| p-value | 0.256 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 49 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 103.0 |
| K Statistic | -0.322 |
| p-value | 0.466 |