Assessment of Structural Intolerance and Durability
General Structure Information 4fdj GALNS the molecular basis of mucopolysaccharidosis iv a, complex with galnac 2.81Å AUTH Y.RIVERA-COLON,E.K.SCHUTSKY,A.Z.KITA,S.C.GARMANTITL THE STRUCTURE OF HUMAN GALNS REVEALS THE MOLECULAR BASIS FORTITL 2 MUCOPOLYSACCHARIDOSIS IV A.REF J.MOL.BIOL. V. 423 736 2012REFN ISSN 0022-2836PMID 22940367DOI 10.1016/J.JMB.2012.08.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1hci ACTN2 crystal structure of the rod domain of alpha-actinin 2.8Å AUTH J.YLANNE,K.SCHEFFZEK,P.YOUNG,M.SARASTETITL CRYSTAL STRUCTURE OF THE ALPHA-ACTININ ROD REVEALSTITL 2 AN EXTENSIVE TORSIONAL TWISTREF STRUCTURE V. 9 597 2001REFN ISSN 0969-2126PMID 11470434DOI 10.1016/S0969-2126(01)00619-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xfd DPP6 structure of a human a-type potassium channel accelerating factor dppx, a member of the dipeptidyl aminopeptidase family 3.0Å AUTH P.STROP,A.J.BANKOVICH,K.C.HANSEN,K.C.GARCIA,A.T.BRUNGERTITL STRUCTURE OF A HUMAN A-TYPE POTASSIUM CHANNEL INTERACTINGTITL 2 PROTEIN DPPX, A MEMBER OF THE DIPEPTIDYL AMINOPEPTIDASETITL 3 FAMILYREF J.MOL.BIOL. V. 343 1055 2004REFN ISSN 0022-2836PMID 15476821DOI 10.1016/J.JMB.2004.09.003 Variant Set […]
General Structure Information 3c59 GLP1R crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain 2.3Å AUTH S.RUNGE,H.THOGERSEN,K.MADSEN,J.LAU,R.RUDOLPHTITL CRYSTAL STRUCTURE OF THE LIGAND-BOUND GLUCAGON-LIKETITL 2 PEPTIDE-1 RECEPTOR EXTRACELLULAR DOMAINREF J.BIOL.CHEM. V. 283 11340 2008REFN ISSN 0021-9258PMID 18287102DOI 10.1074/JBC.M708740200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j72 CAPG crystal structure of mutant macrophage capping protein (cap g) with actin-severing activity in the ca2+-free form 2.5Å AUTH S.M.VOROBIEV,F.S.SOUTHWICK,B.STOROKOPYTOV,S.C.ALMOTITL CRYSTAL STRUCTURE OF MUTANT HUMAN MACROPHAGE CAPPING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1lmj FBN1 nmr study of the fibrillin-1 cbegf12-13 pair of ca2+ binding epidermal growth factor-like domains -1.0Å AUTH R.S.SMALLRIDGE,P.WHITEMAN,J.M.WERNER,I.D.CAMPBELL,AUTH 2 P.A.HANDFORD,A.K.DOWNINGTITL SOLUTION STRUCTURE AND DYNAMICS OF A CALCIUMTITL 2 BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAIN PAIRTITL 3 FROM THE NEONATAL REGION OF HUMAN FIBRILLIN-1.REF J.BIOL.CHEM. V. 278 12199 2003REFN ISSN 0021-9258PMID 12511552DOI 10.1074/JBC.M208266200 […]
General Structure Information 2kax S100A5 solution structure and dynamics of s100a5 in the apo and ca2+ -bound states -1.0Å AUTH I.BERTINI,S.DAS GUPTA,X.HU,T.KARAVELAS,C.LUCHINAT,AUTH 2 G.PARIGI,J.YUANTITL SOLUTION STRUCTURE AND DYNAMICS OF S100A5 IN THETITL 2 APO AND CA2+-BOUND STATESREF J.BIOL.INORG.CHEM. V. 14 1097 2009REFN ISSN 0949-8257PMID 19536568DOI 10.1007/S00775-009-0553-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1wz9 SERPINB5 the 2.1 a structure of a tumour suppressing serpin 2.1Å AUTH R.H.LAW,J.A.IRVING,A.M.BUCKLE,K.RUZYLA,M.BUZZA,AUTH 2 T.A.BASHTANNYK-PUHALOVICH,T.C.BEDDOE,K.NGUYEN,AUTH 3 D.M.WORRALL,S.P.BOTTOMLEY,P.I.BIRD,J.ROSSJOHN,AUTH 4 J.C.WHISSTOCKTITL THE HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMANTITL 2 TUMOR SUPPRESSOR MASPIN REVEALS A NOVELTITL 3 CONFORMATIONAL SWITCH IN THE G-HELIX.REF J.BIOL.CHEM. V. 280 22356 2005REFN ISSN 0021-9258PMID 15760906DOI 10.1074/JBC.M412043200 Variant Set […]
General Structure Information 3g81 SFTPD crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with alpha methyl mannoside 1.8Å AUTH E.CROUCH,K.HARTSHORN,T.HORLACHER,B.MCDONALD,K.SMITH,AUTH 2 T.CAFARELLA,B.SEATON,P.H.SEEBERGER,J.HEADTITL RECOGNITION OF MANNOSYLATED LIGANDS AND INFLUENZA A VIRUS BYTITL 2 HUMAN SURFACTANT PROTEIN D: CONTRIBUTIONS OF AN EXTENDEDTITL 3 SITE AND RESIDUE 343.REF BIOCHEMISTRY […]
General Structure Information 4fl2 SYK structural and biophysical characterization of the syk activation switch 2.19Å AUTH U.GRADLER,D.SCHWARZ,V.DRESING,D.MUSIL,J.BOMKE,M.FRECH,AUTH 2 H.GREINER,S.JAKEL,T.RYSIOK,D.MULLER-POMPALLA,A.WEGENERTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYKTITL 2 ACTIVATION SWITCH.REF J.MOL.BIOL. V. 425 309 2013REFN ISSN 0022-2836PMID 23154170DOI 10.1016/J.JMB.2012.11.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants