General Structure Information
| PDB ID | 1wz9 |
| HGNC Gene Label(s) | SERPINB5 |
| Structure Name | the 2.1 a structure of a tumour suppressing serpin |
| Resolution | 2.1Å |
| Reference | AUTH R.H.LAW,J.A.IRVING,A.M.BUCKLE,K.RUZYLA,M.BUZZA,AUTH 2 T.A.BASHTANNYK-PUHALOVICH,T.C.BEDDOE,K.NGUYEN,AUTH 3 D.M.WORRALL,S.P.BOTTOMLEY,P.I.BIRD,J.ROSSJOHN,AUTH 4 J.C.WHISSTOCKTITL THE HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMANTITL 2 TUMOR SUPPRESSOR MASPIN REVEALS A NOVELTITL 3 CONFORMATIONAL SWITCH IN THE G-HELIX.REF J.BIOL.CHEM. V. 280 22356 2005REFN ISSN 0021-9258PMID 15760906DOI 10.1074/JBC.M412043200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 355 |
| Number Of SNVs | 96 |
| Number Of Permutations | 17040 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.015 |
| p-value | 0.921 |
COSMIC
| Number Of Residues | 355 |
| Number Of SNVs | 8 |
| Number Of Permutations | 2076 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.036 |
| p-value | 0.667 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 96 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.034 |
| p-value | 0.83 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
