Assessment of Structural Intolerance and Durability
General Structure Information 2w5a NEK2 human nek2 kinase adp-bound 1.55Å AUTH I.WESTWOOD,D.M.CHEARY,J.E.BAXTER,M.W.RICHARDS,AUTH 2 R.L.VAN MONTFORT,A.M.FRY,R.BAYLISSTITL INSIGHTS INTO THE CONFORMATIONAL VARIABILITY ANDTITL 2 REGULATION OF HUMAN NEK2 KINASE.REF J.MOL.BIOL. V. 386 476 2009REFN ISSN 0022-2836PMID 19124027DOI 10.1016/J.JMB.2008.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dat SMARCA2 solution structure of the bromodomain of human swi/snf related matrix associated actin dependent regulator of cromatin subfamily a member 2 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,K.SAITO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BROMODOMAIN OF HUMANTITL 2 SWI/SNF RELATED MATRIX ASSOCIATED ACTIN DEPENDENTTITL 3 REGULATOR OF CROMATIN SUBFAMILY A MEMBER 2REF TO BE PUBLISHEDREFN […]
General Structure Information 4f7s CDK8 crystal structure of human cdk8/cycc in the dmg-in conformation 2.2Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o10 CSRP3 solution structure of the n-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o13 CSRP3 solution structure of the c-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1t77 LRBA crystal structure of the ph-beach domains of human lrba/bgl 2.4Å AUTH D.GEBAUER,J.LI,G.JOGL,Y.SHEN,D.G.MYSZKA,L.TONGTITL CRYSTAL STRUCTURE OF THE PH-BEACH DOMAINS OF HUMANTITL 2 LRBA/BGLREF BIOCHEMISTRY V. 43 14873 2004REFN ISSN 0006-2960PMID 15554694DOI 10.1021/BI049498Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2eyz CRK ct10-regulated kinase isoform ii -1.0Å AUTH Y.KOBASHIGAWA,M.SAKAI,M.NAITO,M.YOKOCHI,H.KUMETA,AUTH 2 Y.MAKINO,K.OGURA,S.TANAKA,F.INAGAKITITL STRUCTURAL BASIS FOR THE TRANSFORMING ACTIVITY OFTITL 2 HUMAN CANCER-RELATED SIGNALING ADAPTOR PROTEIN CRK.REF NAT.STRUCT.MOL.BIOL. V. 14 503 2007REFN ISSN 1545-9993PMID 17515907DOI 10.1038/NSMB1241 Variant Set Distributions Mapped Variants
General Structure Information 2kw3 RFX5 heterotrimeric interaction between rfx5 and rfxap -1.0Å AUTH K.M.LAIRD,L.L.BRIGGS,J.M.BOSS,M.F.SUMMERS,C.W.GARVIETITL SOLUTION STRUCTURE OF THE HETEROTRIMERIC COMPLEX BETWEENTITL 2 RFX5 AND RFXAP REVEALS MOLECULAR DETAILS ASSOCIATED WITHTITL 3 MHCII GENE EXPRESSIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lwk CRYBA4 crystal structure of human beta-crystallin a4 (cryba4) 1.7Å AUTH A.CHAIKUAD,N.SHAFQAT,T.KROJER,W.W.YUE,R.COCKING,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,A.C.W.PIKE,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-CRYSTALLIN A4 (CRYBA4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x6h CTCF solution structures of the c2h2 type zinc finger domain of human transcriptional repressor ctcf -1.0Å AUTH M.SATO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN TRANSCRIPTIONAL REPRESSOR CTCFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants