General Structure Information
| PDB ID | 3lwk |
| HGNC Gene Label(s) | CRYBA4 |
| Structure Name | crystal structure of human beta-crystallin a4 (cryba4) |
| Resolution | 1.7Å |
| Reference | AUTH A.CHAIKUAD,N.SHAFQAT,T.KROJER,W.W.YUE,R.COCKING,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,A.C.W.PIKE,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-CRYSTALLIN A4 (CRYBA4)REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 180 |
| Number Of SNVs | 50 |
| Number Of Permutations | 5359 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.099 |
| p-value | 0.03 |
COSMIC
| Number Of Residues | 180 |
| Number Of SNVs | 6 |
| Number Of Permutations | 989 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.067 |
| p-value | 0.115 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.221 |
| p-value | 0.37 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
