Assessment of Structural Intolerance and Durability
General Structure Information 1b22 RAD51 rad51 (n-terminal domain) -1.0Å AUTH H.AIHARA,Y.ITO,H.KURUMIZAKA,S.YOKOYAMA,T.SHIBATATITL THE N-TERMINAL DOMAIN OF THE HUMAN RAD51 PROTEINTITL 2 BINDS DNA: STRUCTURE AND A DNA BINDING SURFACE ASTITL 3 REVEALED BY NMR.REF J.MOL.BIOL. V. 290 495 1999REFN ISSN 0022-2836PMID 10390347DOI 10.1006/JMBI.1999.2904 Variant Set Distributions Mapped Variants
General Structure Information 2knx LRP1 solution structure of complement repeat cr17 from lrp-1 -1.0Å AUTH M.GUTTMAN,J.H.PRIETO,T.M.HANDEL,P.J.DOMAILLE,E.A.KOMIVESTITL STRUCTURE OF THE MINIMAL INTERFACE BETWEEN APOE AND LRP.REF J.MOL.BIOL. V. 398 306 2010REFN ISSN 0022-2836PMID 20303980DOI 10.1016/J.JMB.2010.03.022 Variant Set Distributions Mapped Variants
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2odd RUNX1T1 solution structure of the mynd domain from aml1-eto complexed with smrt, a corepressor -1.0Å AUTH Y.LIU,W.CHEN,J.GAUDET,M.D.CHENEY,L.ROUDAIA,AUTH 2 T.CIERPICKI,R.C.KLET,K.HARTMAN,T.M.LAUE,N.A.SPECK,AUTH 3 J.H.BUSHWELLERTITL STRUCTURAL BASIS FOR RECOGNITION OF SMRT/N-COR BYTITL 2 THE MYND DOMAIN AND ITS CONTRIBUTION TO AML1/ETOSTITL 3 ACTIVITY.REF CANCER CELL V. 11 483 2007REFN ISSN 1535-6108PMID 17560331DOI 10.1016/J.CCR.2007.04.010 Variant Set […]
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1uhl NR1H3 crystal structure of the lxralfa-rxrbeta lbd heterodimer 2.9Å AUTH S.SVENSSON,T.OSTBERG,M.JACOBSSON,C.NORSTROM,AUTH 2 K.STEFANSSON,D.HALLEN,I.C.JOHANSSON,K.ZACHRISSON,AUTH 3 D.OGG,L.JENDEBERGTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OFTITL 2 LXRALPHA AND RXRBETA LIGAND-BINDING DOMAINS IN ATITL 3 FULLY AGONISTIC CONFORMATIONREF EMBO J. V. 22 4625 2003REFN ISSN 0261-4189PMID 12970175DOI 10.1093/EMBOJ/CDG456 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1fqv SKP2 insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex 2.8Å AUTH B.A.SCHULMAN,A.C.CARRANO,P.D.JEFFREY,Z.BOWEN,AUTH 2 E.R.KINNUCAN,M.S.FINNIN,S.J.ELLEDGE,J.W.HARPER,AUTH 3 M.PAGANO,N.P.PAVLETICHTITL INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THETITL 2 STRUCTURE OF THE SKP1-SKP2 COMPLEX.REF NATURE V. 408 381 2000REFN ISSN 0028-0836PMID 11099048DOI 10.1038/35042620 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3cyy TJP1 the crystal structure of zo-1 pdz2 in complex with the cx43 peptide 2.4Å AUTH J.CHEN,L.PAN,Z.WEI,Y.ZHAO,M.ZHANGTITL DOMAIN-SWAPPED DIMERIZATION OF ZO-1 PDZ2 GENERATES SPECIFICTITL 2 AND REGULATORY CONNEXIN43-BINDING SITESREF EMBO J. V. 27 2113 2008REFN ISSN 0261-4189PMID 18636092DOI 10.1038/EMBOJ.2008.138 Variant Set Distributions Mapped Variants
General Structure Information 3ull SSBP1 human mitochondrial single-stranded dna binding protein 2.4Å AUTH C.YANG,U.CURTH,C.URBANKE,C.KANGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIALTITL 2 SINGLE-STRANDED DNA BINDING PROTEIN AT 2.4 ATITL 3 RESOLUTION.REF NAT.STRUCT.BIOL. V. 4 153 1997REFN ISSN 1072-8368PMID 9033597DOI 10.1038/NSB0297-153 Variant Set Distributions Mapped Variants
General Structure Information 1jj7 TAP1 crystal structure of the c-terminal atpase domain of human tap1 2.4Å AUTH R.GAUDET,D.C.WILEYTITL STRUCTURE OF THE ABC ATPASE DOMAIN OF HUMAN TAP1,TITL 2 THE TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING.REF EMBO J. V. 20 4964 2001REFN ISSN 0261-4189PMID 11532960DOI 10.1093/EMBOJ/20.17.4964 Variant Set Distributions Mapped Variants