Assessment of Structural Intolerance and Durability
General Structure Information 2cs3 IRF2BPL solution structure of the zf-c3hc4 domain of human kiaa1865 -1.0Å AUTH K.INOUE,K.SAITOH,F.HAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-C3HC4 DOMAIN OF HUMANTITL 2 KIAA1865REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dmq LHX9 solution structure of the homeobox domain of lim/homeobox protein lhx9 -1.0Å AUTH S.OHNISHI,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HOMEOBOX DOMAIN OFTITL 2 LIM/HOMEOBOX PROTEIN LHX9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lxl VTA1 lip5(mit)2 -1.0Å AUTH J.J.SKALICKY,J.ARII,D.M.WENZEL,W.M.STUBBLEFIELD,A.KATSUYAMA,AUTH 2 N.T.UTER,M.BAJOREK,D.G.MYSZKA,W.I.SUNDQUISTTITL INTERACTIONS OF THE HUMAN LIP5 REGULATORY PROTEIN WITHTITL 2 ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT.REF J.BIOL.CHEM. V. 287 43910 2012REFN ISSN 0021-9258PMID 23105106DOI 10.1074/JBC.M112.417899 Variant Set Distributions Mapped Variants
General Structure Information 2cqm MRPL17 solution structure of the mitochondrial ribosomal protein l17 isolog -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE MITOCHONDRIAL RIBOSOMALTITL 2 PROTEIN L17 ISOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hl2 SEPSECS the crystal structure of the human sepsecs-trnasec complex 2.81Å AUTH S.PALIOURA,R.L.SHERRER,T.A.STEITZ,D.SOLL,AUTH 2 M.SIMONOVICTITL THE HUMAN SEPSECS-TRNASEC COMPLEX REVEALS THETITL 2 MECHANISM OF SELENOCYSTEINE FORMATION.REF SCIENCE V. 325 321 2009REFN ISSN 0036-8075PMID 19608919DOI 10.1126/SCIENCE.1173755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3l4g FARSB crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase 3.3Å AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1ixd CYLD solution structure of the cap-gly domain from human cylindromatosis tomour-suppressor cyld -1.0Å AUTH K.SAITO,T.KIGAWA,S.KOSHIBA,K.SATO,Y.MATSUO,AUTH 2 A.SAKAMOTO,T.TAKAGI,M.SHIROUZU,T.YABUKI,E.NUNOKAWA,AUTH 3 E.SEKI,T.MATSUDA,M.AOKI,Y.MIYATA,N.HIRAKAWA,AUTH 4 M.INOUE,T.TERADA,T.NAGASE,R.KIKUNO,M.NAKAYAMA,AUTH 5 O.OHARA,A.TANAKA,S.YOKOYAMATITL THE CAP-GLY DOMAIN OF CYLD ASSOCIATES WITH THETITL 2 PROLINE-RICH SEQUENCE IN NEMO/IKKGAMMAREF STRUCTURE V. 12 1719 2004REFN ISSN 0969-2126PMID 15341735DOI 10.1016/J.STR.2004.07.012 Variant Set Distributions Mapped Variants
General Structure Information 2io1 SENP2 crystal structure of human senp2 in complex with presumo-3 2.6Å AUTH D.REVERTER,C.D.LIMATITL STRUCTURAL BASIS FOR SENP2 PROTEASE INTERACTIONSTITL 2 WITH SUMO PRECURSORS AND CONJUGATED SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 13 1060 2006REFN ISSN 1545-9993PMID 17099700DOI 10.1038/NSMB1168 Variant Set Distributions Mapped Variants
General Structure Information 2cmw CSNK1G1 structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target) 1.75Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,P.SAVITSKY,F.NIESEN,F.SOBOTT,AUTH 2 O.FEDOROV,A.C.W.PIKE,F.VON DELFT,M.SUNDSTROM,C.ARROWSMITH,AUTH 3 A.EDWARDS,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITHTITL 2 2-(2-HYDROXYETHYLAMINO)-6-TITL 3 (3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]