Assessment of Structural Intolerance and Durability
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lg1 AKAP13 solution structure of the human akap13 ph domain and stabilizing dh helix -1.0Å AUTH M.LENOIR,M.SUGAWARA,J.KAUR,L.J.BALL,M.OVERDUINTITL STRUCTURAL INSIGHTS INTO THE ACTIVATION OF THE RHOA GTPASETITL 2 BY THE LBC ONCOPROTEIN.REF J.BIOL.CHEM. V. 3 215 2014REFN ISSN 0021-9258PMID 24993829DOI 10.1074/JBC.M114.561787 Variant Set Distributions Mapped Variants
General Structure Information 1nrv GRB10 crystal structure of the sh2 domain of grb10 1.65Å AUTH E.G.STEIN,R.GHIRLANDO,S.R.HUBBARDTITL STRUCTURAL BASIS FOR DIMERIZATION OF THE GRB10 SRCTITL 2 HOMOLOGY 2 DOMAIN. IMPLICATIONS FOR LIGANDTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 278 13257 2003REFN ISSN 0021-9258PMID 12551896DOI 10.1074/JBC.M212026200 Variant Set Distributions Mapped Variants
General Structure Information 3w9y DLG1 crystal structure of the human dlg1 guanylate kinase domain 2.2Å AUTH S.MORI,Y.TEZUKA,A.ARAKAWA,N.HANDA,M.SHIROUZU,T.AKIYAMA,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GUANYLATE KINASE DOMAIN FROM DISCSTITL 2 LARGE HOMOLOG 1 (DLG1/SAP97)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 435 334 2013REFN ISSN 0006-291XPMID 23624197DOI 10.1016/J.BBRC.2013.04.056 Variant Set Distributions Mapped Variants
General Structure Information 4d8o ANK2 crystal structure of the ankyrin-b zu5-zu5-upa-dd tandem 2.2Å AUTH C.WANG,C.YU,F.YE,Z.WEI,M.ZHANGTITL STRUCTURE OF THE ZU5-ZU5-UPA-DD TANDEM OF ANKYRIN-B REVEALSTITL 2 INTERACTION SURFACES NECESSARY FOR ANKYRIN FUNCTIONREF PROC.NATL.ACAD.SCI.USA V. 109 4822 2012REFN ISSN 0027-8424PMID 22411828DOI 10.1073/PNAS.1200613109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v0o FCHO2 fcho2 f-bar domain 2.3Å AUTH W.M.HENNE,H.M.KENT,M.J.G.FORD,B.G.HEDGE,O.DAUMKE,AUTH 2 P.J.BUTLER,R.MITTAL,R.LANGEN,P.R.EVANS,H.T.MCMAHONTITL STRUCTURE AND ANALYSIS OF FCHO2 F-BAR DOMAIN: ATITL 2 DIMERIZING AND MEMBRANE RECRUITMENT MODULE THATTITL 3 EFFECTS MEMBRANE CURVATURE.REF STRUCTURE V. 15 839 2007REFN ISSN 0969-2126PMID 17540576DOI 10.1016/J.STR.2007.05.002 Variant Set Distributions Mapped Variants
General Structure Information 2v0o FCHO2 fcho2 f-bar domain 2.3Å AUTH W.M.HENNE,H.M.KENT,M.J.G.FORD,B.G.HEDGE,O.DAUMKE,AUTH 2 P.J.BUTLER,R.MITTAL,R.LANGEN,P.R.EVANS,H.T.MCMAHONTITL STRUCTURE AND ANALYSIS OF FCHO2 F-BAR DOMAIN: ATITL 2 DIMERIZING AND MEMBRANE RECRUITMENT MODULE THATTITL 3 EFFECTS MEMBRANE CURVATURE.REF STRUCTURE V. 15 839 2007REFN ISSN 0969-2126PMID 17540576DOI 10.1016/J.STR.2007.05.002 Variant Set Distributions Mapped Variants