General Structure Information
| PDB ID | 4d8o |
| HGNC Gene Label(s) | ANK2 |
| Structure Name | crystal structure of the ankyrin-b zu5-zu5-upa-dd tandem |
| Resolution | 2.2Å |
| Reference | AUTH C.WANG,C.YU,F.YE,Z.WEI,M.ZHANGTITL STRUCTURE OF THE ZU5-ZU5-UPA-DD TANDEM OF ANKYRIN-B REVEALSTITL 2 INTERACTION SURFACES NECESSARY FOR ANKYRIN FUNCTIONREF PROC.NATL.ACAD.SCI.USA V. 109 4822 2012REFN ISSN 0027-8424PMID 22411828DOI 10.1073/PNAS.1200613109 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 429 |
| Number Of SNVs | 82 |
| Number Of Permutations | 53935 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.294 |
| p-value | 0.048 |
COSMIC
| Number Of Residues | 429 |
| Number Of SNVs | 11 |
| Number Of Permutations | 4625 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.618 |
| p-value | 0.478 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 82 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.075 |
| p-value | 0.094 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
