Assessment of Structural Intolerance and Durability
General Structure Information 3i3n KLHL11 crystal structure of the btb-back domains of human klhl11 2.6Å AUTH J.W.MURRAY,C.D.O.COOPER,T.KROJER,P.MAHAJAN,E.SALAH,AUTH 2 T.KEATES,P.SAVITSKY,A.C.W.PIKE,A.ROOS,J.MUNIZ,AUTH 3 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,S.KNAPP,A.BULLOCK,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMANTITL 2 KLHL11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2edj ROBO2 solution structure of the fifth ig-like domain from human roundabout homolog 2 -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH IG-LIKE DOMAINTITL 2 FROM HUMAN ROUNDABOUT HOMOLOG 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q4k C11orf68 ensemble refinement of the protein crystal structure of gene product from homo sapiens hs.433573 2.5Å AUTH E.J.LEVIN,D.A.KONDRASHOV,G.E.WESENBERG,G.N.PHILLIPSTITL ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURES:TITL 2 VALIDATION AND APPLICATION.REF STRUCTURE V. 15 1040 2007REFN ISSN 0969-2126PMID 17850744DOI 10.1016/J.STR.2007.06.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1uw4 UPF2 the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants
General Structure Information 2yul SOX17 solution structure of the hmg box of human transcription factor sox-17 -1.0Å AUTH H.ABE,N.TOCHIO,K.MIYAMOTO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HMG BOX OF HUMANTITL 2 TRANSCRIPTION FACTOR SOX-17REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2epp PATZ1 solution structure of the first c2h2 type zinc finger domain of zinc finger protein 278 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 278REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4day RMI1 crystal structure of the rmi core complex with mm2 peptide from fancm 3.3Å AUTH K.A.HOADLEY,Y.XUE,C.LING,M.TAKATA,W.WANG,J.L.KECKTITL DEFINING THE MOLECULAR INTERFACE THAT CONNECTS THE FANCONITITL 2 ANEMIA PROTEIN FANCM TO THE BLOOM SYNDROME DISSOLVASOME.REF PROC.NATL.ACAD.SCI.USA V. 109 4437 2012REFN ISSN 0027-8424PMID 22392978DOI 10.1073/PNAS.1117279109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3lq9 DDIT4 crystal strucure of human redd1, a hypoxia-induced regulator of mtor 2.0Å AUTH S.VEGA-RUBIN-DE-CELIS,Z.ABDALLAH,L.KINCH,AUTH 2 N.V.GRISHIN,J.BRUGAROLAS,X.ZHANGTITL STRUCTURAL ANALYSIS AND FUNCTIONAL IMPLICATIONS OFTITL 2 THE NEGATIVE MTORC1 REGULATOR REDD1.REF BIOCHEMISTRY V. 49 2491 2010REFN ISSN 0006-2960PMID 20166753DOI 10.1021/BI902135E Variant Set Distributions Mapped Variants
General Structure Information 3gbj KIF13B crystal structure of the motor domain of kinesin kif13b bound with adp 2.1Å AUTH Y.TONG,L.SHEN,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESINTITL 2 KIF13B BOUND WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants