General Structure Information
| PDB ID | 3gbj |
| HGNC Gene Label(s) | KIF13B |
| Structure Name | crystal structure of the motor domain of kinesin kif13b bound with adp |
| Resolution | 2.1Å |
| Reference | AUTH Y.TONG,L.SHEN,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESINTITL 2 KIF13B BOUND WITH ADPREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 294 |
| Number Of SNVs | 70 |
| Number Of Permutations | 16372 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.181 |
| p-value | 0.165 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 8:29120538 | K>R | C:5 | (-13.55, -62.86, -33.03) | |
| 8:29102938 | K>R | C:25 | (-7.10, -35.92, -11.27) | |
| 8:29102936 | C>R | C:26 | (-5.31, -38.34, -14.01) | |
| 8:29102925 | D>E | C:29 | (-2.40, -44.30, -16.16) | |
| 8:29102915 | N>D | C:33 | (-2.27, -53.07, -23.43) | |
| 8:29102909 | V>I | C:35 | (-5.61, -49.61, -18.26) | |
| 8:29048574 | rs558541168 | V>M | C:55 | (-4.86, -53.46, -13.88) |
| 8:29048564 | rs372924504 | Y>C | C:58 | (-8.17, -54.05, -22.02) |
| 8:29048542 | rs538851654 | M>I | C:65 | (-5.21, -37.15, -22.79) |
| 8:29048544 | M>V | C:65 | (-5.21, -37.15, -22.79) | |
| 8:29048538 | rs199660413 | E>Q | C:67 | (-1.64, -34.24, -29.54) |
| 8:29048535 | rs376813155 | S>T | C:68 | (1.75, -33.24, -28.10) |
| 8:29048529 | K>Q | C:70 | (3.60, -38.30, -30.56) | |
| 8:29046115 | I>T | C:78 | (-4.33, -44.52, -34.79) | |
| 8:29046106 | K>T | C:81 | (-5.64, -48.46, -38.38) | |
| 8:29046107 | K>Q | C:81 | (-5.64, -48.46, -38.38) | |
| 8:29046073 | F>S | C:92 | (-14.64, -56.49, -49.21) | |
| 8:29046069 | D>E | C:93 | (-13.75, -61.88, -46.86) | |
| 8:29046062 | N>D | C:96 | (-21.29, -60.72, -40.76) | |
| 8:29046059 | A>T | C:97 | (-19.51, -57.24, -38.33) | |
| 8:29046056 | C>G | C:98 | (-19.92, -55.60, -35.06) | |
| 8:29046044 | Y>H | C:102 | (-19.79, -49.55, -22.95) | |
| 8:29046040 | rs371915765 | G>A | C:103 | (-20.00, -45.62, -22.34) |
| 8:29043971 | T>I | C:112 | (-14.95, -42.82, -31.77) | |
| 8:29043969 | M>V | C:113 | (-18.26, -44.48, -34.08) | |
| 8:29043923 | S>T | C:128 | (-13.85, -43.90, -47.85) | |
| 8:29043915 | rs143674632 | F>L | C:131 | (-17.71, -46.63, -51.99) |
| 8:29043911 | E>G | C:132 | (-10.58, -46.18, -52.39) | |
| 8:29043892 | E>D | C:138 | (-16.00, -51.73, -60.01) | |
| 8:29043857 | Y>C | C:150 | (-28.17, -44.08, -38.90) | |
| 8:29043852 | E>K | C:152 | (-32.81, -44.19, -32.55) | |
| 8:29043846 | Y>H | C:154 | (-35.67, -44.29, -26.43) | |
| 8:29043830 | R>Q | C:159 | (-36.02, -42.36, -35.04) | |
| 8:29043827 | D>V | C:160 | (-35.54, -44.32, -40.05) | |
| 8:29043819 | D>N | C:163 | (-37.31, -41.62, -43.79) | |
| 8:29039521 | S>T | C:167 | (-42.69, -37.13, -33.19) | |
| 8:29039518 | R>H | C:168 | (-40.22, -39.74, -32.66) | |
| 8:29039512 | T>M | C:170 | (-41.63, -45.87, -33.75) | |
| 8:29039509 | L>S | C:171 | (-40.67, -48.43, -37.17) | |
| 8:29039503 | V>D | C:173 | (-40.01, -55.09, -34.38) | |
| 8:29039496 | E>D | C:175 | (-41.51, -61.71, -36.73) | |
| 8:29039494 | rs374562840 | H>L | C:176 | (-39.87, -63.20, -40.37) |
| 8:29039490 | rs200153696 | S>R | C:177 | (-41.45, -67.71, -37.71) |
| 8:29039492 | S>G | C:177 | (-41.45, -67.71, -37.71) | |
| 8:29039480 | P>A | C:181 | (-35.93, -60.00, -36.20) | |
| 8:29039470 | D>A | C:184 | (-42.22, -52.99, -40.80) | |
| 8:29039468 | G>R | C:185 | (-40.11, -49.83, -42.98) | |
| 8:29039459 | rs369434746 | K>E | C:188 | (-32.16, -51.31, -47.43) |
| 8:29039440 | Y>C | C:194 | (-18.19, -40.54, -48.71) | |
| 8:29037745 | S>L | C:199 | (-26.15, -37.77, -47.56) | |
| 8:29037718 | R>H | C:208 | (-28.52, -39.09, -33.31) | |
| 8:29037719 | R>C | C:208 | (-28.52, -39.09, -33.31) | |
| 8:29037683 | S>G | C:220 | (-27.62, -40.34, -24.18) | |
| 8:29037671 | A>S | C:224 | (-26.96, -45.95, -32.92) | |
| 8:29037655 | T>I | C:229 | (-25.21, -54.58, -46.89) | |
| 8:29037656 | rs576265435 | T>A | C:229 | (-25.21, -54.58, -46.89) |
| 8:29037653 | L>F | C:230 | (-20.81, -55.47, -49.29) | |
| 8:29037644 | T>S | C:233 | (-21.42, -60.31, -57.79) | |
| 8:29035077 | G>S | C:247 | (-21.44, -58.26, -46.03) | |
| 8:29035065 | L>M | C:251 | (-21.11, -49.35, -37.36) | |
| 8:29035040 | R>Q | C:259 | (-26.24, -44.84, -13.40) | |
| 8:29034992 | N>S | C:275 | (-33.80, -51.27, -20.31) | |
| 8:29033688 | T>I | C:281 | (-26.41, -56.67, -19.44) | |
| 8:29033689 | T>A | C:281 | (-26.41, -56.67, -19.44) | |
| 8:29033686 | T>S | C:282 | (-27.85, -58.76, -22.97) | |
| 8:29033623 | V>F | C:303 | (-27.05, -66.71, -26.50) | |
| 8:29033613 | rs375632161 | R>H | C:306 | (-34.04, -62.37, -27.28) |
| 8:29025095 | L>P | C:318 | (-23.11, -61.84, -33.39) | |
| 8:29025086 | N>T | C:321 | (-18.04, -66.14, -38.29) | |
| 8:29025070 | M>I | C:326 | (-15.78, -52.97, -27.42) | |
| 8:29025072 | M>V | C:326 | (-15.78, -52.97, -27.42) | |
| 8:29025048 | rs142831178 | A>T | C:334 | (-11.38, -38.37, -10.70) |
| 8:29025045 | rs140358824 | D>N | C:335 | (-14.81, -36.60, -11.88) |
| 8:29025035 | D>G | C:338 | (-17.37, -44.75, -9.83) | |
| 8:29025036 | D>H | C:338 | (-17.37, -44.75, -9.83) | |
| 8:29025027 | L>V | C:341 | (-14.22, -49.38, -12.40) | |
| 8:29025015 | R>W | C:345 | (-15.10, -53.81, -13.10) | |
| 8:29025000 | A>P | C:350 | (-15.51, -59.33, -23.08) |