Assessment of Structural Intolerance and Durability
General Structure Information 2crf RANBP3 solution structure of the ran_bp1 domain of ran-binding protein-3 -1.0Å AUTH H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RAN_BP1 DOMAIN OFTITL 2 RAN-BINDING PROTEIN-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gao SAR1A crystal structure of human sar1a in complex with gdp 2.0Å AUTH J.WANG,S.DIMOV,W.TEMPEL,D.YANIW,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN SAR1A IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q3f RRAGD x-ray crystal structure of putative human ras-related gtp binding d in complex with gmppnp 2.1Å AUTH A.M.MULICHAK,W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,AUTH 2 R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 3 J.WEIGELT,L.J.KEEFE,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-RELATED GTP-BINDINGTITL 2 D.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k9i CD209 complex of dc-sign and glcnac2man3 2.5Å AUTH H.FEINBERG,D.A.MITCHELL,K.DRICKAMER,W.I.WEISTITL STRUCTURAL BASIS FOR SELECTIVE RECOGNITION OFTITL 2 OLIGOSACCHARIDES BY DC-SIGN AND DC-SIGNR.REF SCIENCE V. 294 2163 2001REFN ISSN 0036-8075PMID 11739956DOI 10.1126/SCIENCE.1066371 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r55 STARD5 human star-related lipid transfer protein 5 2.5Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 4hfg RPRD1B cid of human rprd1b 2.0Å AUTH Z.NI,C.XU,W.TEMPEL,M.EL BAKKOURI,P.LOPPNAU,X.GUO,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,J.F.GREENBLATTTITL CID OF HUMAN RPRD1BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1eaz PLEKHA1 crystal structure of the phosphoinositol (3,4)-bisphosphate binding ph domain of tapp1 from human. 1.4Å AUTH C.C.THOMAS,S.DOWLER,M.DEAK,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF THE PHOSPHATIDYLINOSITOLTITL 2 3,4-BISPHOSPHATE-BINDING PLECKSTRIN HOMOLOGY (PH)TITL 3 DOMAIN OF TANDEM PH-DOMAIN-CONTAINING PROTEIN 1TITL 4 (TAPP1): MOLECULAR BASIS OF LIPID SPECIFICITYREF BIOCHEM.J. V. 358 287 2001REFN ISSN 0264-6021PMID […]
General Structure Information 4e74 PLXNA4 crystal structure of the rho gtpase binding domain of plexin a4a 1.58Å AUTH X.GUAN,H.WANG,W.TEMPEL,A.DONG,Y.TONG,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 A4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1whl CYLD solution structure of the 1st cap-gly domain in human cylindromatosis tumor suppressor cyld -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST CAP-GLY DOMAIN INTITL 2 HUMAN CYLINDROMATOSIS TUMOR SUPPRESSOR CYLDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ega PELI2 crystal structure of pellino2 fha domain at 1.8 angstroms resolution 1.8Å AUTH C.C.LIN,Y.S.HUOH,K.R.SCHMITZ,L.E.JENSEN,K.M.FERGUSONTITL PELLINO PROTEINS CONTAIN A CRYPTIC FHA DOMAIN THAT MEDIATESTITL 2 INTERACTION WITH PHOSPHORYLATED IRAK1.REF STRUCTURE V. 16 1806 2008REFN ISSN 0969-2126PMID 19081057DOI 10.1016/J.STR.2008.09.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]