Assessment of Structural Intolerance and Durability
General Structure Information 1wiz SATB2 solution structure of the first cut domain of kiaa1034 protein -1.0Å AUTH K.INOUE,S.NAMEKI,F.HAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CUT DOMAIN OFTITL 2 KIAA1034 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ae4 UBAP1 the ubap1 subunit of escrt-i interacts with ubiquitin via a novel souba domain 1.65Å AUTH M.AGROMAYOR,N.SOLER,A.CABALLE,T.KUECK,S.M.FREUND,M.D.ALLEN,AUTH 2 M.BYCROFT,O.PERISIC,Y.YE,B.MCDONALD,H.SCHEEL,K.HOFMANN,AUTH 3 S.J.D.NEIL,J.MARTIN-SERRANO,R.L.WILLIAMSTITL THE UBAP1 SUBUNIT OF ESCRT-I INTERACTS WITH UBIQUITIN VIA ATITL 2 SOUBA DOMAIN.REF STRUCTURE V. 20 414 2012REFN ISSN 0969-2126PMID 22405001DOI 10.1016/J.STR.2011.12.013 Variant Set Distributions Mapped Variants
General Structure Information 2jw5 POLL polymerase lambda brct domain -1.0Å AUTH G.A.MUELLER,A.F.MOON,E.F.DEROSE,B.J.DAVIS,AUTH 2 D.A.RAMSDEN,L.C.PEDERSEN,R.E.LONDONTITL POLYMERASE LAMBDA BRCT DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4mqf GABBR1 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist 2-hydroxysaclofen 2.22Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2csk SNX12 solution structure of px domain from human snx12 -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF PX DOMAIN FROM HUMAN SNX12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kzs DAXX daxx helical bundle (dhb) domain -1.0Å AUTH E.ESCOBAR-CABRERA,D.K.LAU,S.GIOVINAZZI,A.M.ISHOV,AUTH 2 L.P.MCINTOSHTITL STRUCTURAL CHARACTERIZATION OF THE DAXX N-TERMINAL HELICALTITL 2 BUNDLE DOMAIN AND ITS COMPLEX WITH RASSF1C.REF STRUCTURE V. 18 1642 2010REFN ISSN 0969-2126PMID 21134643DOI 10.1016/J.STR.2010.09.016 Variant Set Distributions Mapped Variants
General Structure Information 3a8y BAG5 crystal structure of the complex between the bag5 bd5 and hsp70 nbd 2.3Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants
General Structure Information 1wmk DAPK2 human death-associated kinase drp-1, mutant s308d d40 3.6Å AUTH P.KURSULA,G.SHANI,A.KIMCHI,M.WILMANNSTITL STRUCTURE OF THE INHIBITED CONFORMATION OF DRP-1TITL 2 KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c5l PLCE1 structure of plc epsilon ras association domain with hras 1.9Å AUTH T.D.BUNNEY,R.HARRIS,N.L.GANDARILLAS,M.B.JOSEPHS,AUTH 2 S.M.ROE,S.C.SORLI,H.F.PATERSON,F.RODRIGUES-LIMA,AUTH 3 D.ESPOSITO,C.P.PONTING,P.GIESCHIK,L.H.PEARL,AUTH 4 P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO RASTITL 2 ASSOCIATION DOMAINS OF PHOSPHOLIPASE C EPSILONREF MOL.CELL V. 21 495 2006REFN ISSN 1097-2765PMID 16483931DOI 10.1016/J.MOLCEL.2006.01.008 Variant Set Distributions Mapped Variants
General Structure Information 1wi3 SATB2 solution structure of the homeodomain of kiaa1034 protein -1.0Å AUTH K.IZUMI,M.YOSHIDA,F.HAYASHI,R.HATTA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HOMEODOMAIN OF KIAA1034TITL 2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants