1WMK.H | DAPK2

General Structure Information

PDB ID	1wmk
HGNC Gene Label(s)	DAPK2
Structure Name	human death-associated kinase drp-1, mutant s308d d40
Resolution	3.6Å
Reference	AUTH P.KURSULA,G.SHANI,A.KIMCHI,M.WILMANNSTITL STRUCTURE OF THE INHIBITED CONFORMATION OF DRP-1TITL 2 KINASEREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	304
Number Of SNVs	91
Number Of Permutations	15963
Optimal Distance Threshold	10.0
K Statistic	0.047
p-value	0.349

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:64332424	rs373328408 COSM1374017	P>A	H:3	(94.80, 76.88, 26.92)
15:64332409		K>E	H:8	(83.40, 88.82, 32.95)
15:64332384		G>A	H:16	(68.51, 81.44, 29.25)
15:64275940		I>V	H:26	(73.30, 73.37, 35.03)
15:64275937		V>M	H:27	(72.69, 72.89, 30.27)
15:64275924	rs145891572	R>Q	H:31	(71.06, 84.65, 21.82)
15:64275925		R>W	H:31	(71.06, 84.65, 21.82)
15:64275912	rs201545659 COSM3981601	T>M	H:35	(76.75, 86.83, 16.24)
15:64275900	rs200254684	Y>F	H:39	(75.91, 78.94, 19.73)
15:64275892		K>E	H:42	(77.94, 72.12, 30.03)
15:64275888		F>S	H:43	(76.98, 77.19, 33.16)
15:64275876	rs8037614	R>Q	H:47	(86.79, 69.55, 43.22)
15:64275877		R>W	H:47	(86.79, 69.55, 43.22)
15:64275868	rs56047843	R>W	H:50	(91.04, 67.74, 48.54)
15:64275859	rs200808263	R>W	H:53	(78.54, 64.88, 48.88)
15:64275855		R>H	H:54	(77.72, 70.03, 45.87)
15:64275856		R>C	H:54	(77.72, 70.03, 45.87)
15:64275853	rs140788025	G>S	H:55	(82.03, 68.73, 41.66)
15:64275844		R>W	H:58	(90.75, 72.33, 37.01)
15:64275841		E>K	H:59	(92.88, 65.99, 36.15)
15:64275836		E>D	H:60	(87.51, 64.68, 35.05)
15:64275834		I>T	H:61	(87.03, 69.84, 33.27)
15:64275832	rs572424184	E>K	H:62	(91.97, 69.68, 31.84)
15:64275829	rs553905161	R>W	H:63	(90.34, 63.84, 31.10)
15:64275816	rs371887575	I>T	H:67	(88.14, 64.96, 23.82)
15:64275813		L>P	H:68	(85.18, 68.52, 22.76)
15:64275811	rs542492420	R>W	H:69	(90.03, 72.37, 22.26)
15:64275802	rs565512081	L>V	H:72	(86.42, 68.75, 14.00)
15:64275792		N>S	H:75	(77.25, 62.44, 13.13)
15:64275790		V>I	H:76	(79.84, 64.51, 16.56)
15:64275768		Y>C	H:83	(84.38, 81.69, 28.07)
15:64275764		E>D	H:84	(87.90, 79.65, 33.50)
15:64275763	rs142526378	N>D	H:85	(85.10, 81.77, 36.60)
15:64275759	rs201432861 COSM963901	R>H	H:86	(86.38, 81.89, 41.47)
15:64275756		T>I	H:87	(82.37, 79.00, 40.40)
15:64275753		D>V	H:88	(81.39, 77.65, 37.23)
15:64275754	rs148399921	D>N	H:88	(81.39, 77.65, 37.23)
15:64263745		E>D	H:100	(65.92, 61.26, 22.57)
15:64263747	rs190782744	E>K	H:100	(65.92, 61.26, 22.57)
15:64263738	rs553988389 COSM1374014	D>N	H:103	(61.30, 61.01, 20.56)
15:64263725		Q>R	H:107	(56.30, 60.23, 16.32)
15:64263720		E>K	H:109	(53.64, 55.38, 11.13)
15:64263670	rs147197384	D>E	H:125	(79.72, 57.48, 10.61)
15:64263669	rs534412704	G>W	H:126	(81.11, 59.05, 14.67)
15:64263651	rs555303465	T>P	H:132	(90.40, 57.22, 14.07)
15:64263631		F>L	H:138	(83.79, 54.75, 27.63)
15:64231549		I>M	H:145	(71.56, 59.02, 20.35)
15:64231539	rs201994664	D>H	H:149	(65.59, 69.47, 12.98)
15:64231521		P>S	H:155	(66.89, 63.07, 10.76)
15:64231505	rs551687423	I>T	H:160	(75.67, 64.37, 23.57)
15:64231490		A>V	H:165	(85.55, 60.45, 27.64)
15:64231491		A>P	H:165	(85.55, 60.45, 27.64)
15:64231485	COSM963900	E>K	H:167	(92.65, 60.63, 24.95)
15:64231476		D>N	H:170	(98.98, 52.10, 22.86)
15:64231469		V>A	H:172	(98.46, 53.15, 29.34)
15:64231458		N>D	H:176	(86.57, 52.91, 35.95)
15:64231455		I>V	H:177	(83.02, 51.52, 37.76)
15:64231445	rs149502968	T>M	H:180	(74.22, 53.03, 32.58)
15:64231442		P>L	H:181	(73.07, 49.84, 34.36)
15:64231440		E>K	H:182	(70.57, 49.05, 30.37)
15:64231433		V>A	H:184	(77.64, 48.33, 30.53)
15:64231434		V>I	H:184	(77.64, 48.33, 30.53)
15:64231431		A>T	H:185	(80.64, 46.14, 29.33)
15:64222643		V>M	H:189	(81.25, 45.05, 35.44)
15:64222632		E>D	H:192	(88.50, 43.57, 33.43)
15:64222622		L>V	H:196	(87.97, 51.46, 21.50)
15:64221765		V>D	H:205	(72.42, 47.26, 23.68)
15:64221766	rs140850258	V>I	H:205	(72.42, 47.26, 23.68)
15:64221760		T>A	H:207	(70.60, 47.71, 17.96)
15:64221751	COSM963899	L>F	H:210	(66.20, 50.43, 17.71)
15:64218284		G>E	H:213	(62.42, 47.49, 23.32)
15:64218285	rs200851607	G>R	H:213	(62.42, 47.49, 23.32)
15:64218269	rs150637317	L>P	H:218	(66.84, 44.88, 32.39)
15:64218260		T>M	H:221	(67.31, 43.60, 40.30)
15:64218249		T>A	H:225	(71.23, 43.65, 35.25)
15:64218245		L>R	H:226	(75.31, 43.55, 37.09)
15:64218231		A>T	H:231	(76.63, 35.71, 31.95)
15:64218227		V>A	H:232	(76.49, 36.71, 28.39)
15:64218224		S>N	H:233	(72.23, 36.33, 29.29)
15:64218219	rs370739509	D>N	H:235	(66.91, 35.39, 25.26)
15:64218210	COSM470947	E>K	H:238	(59.72, 34.46, 18.42)
15:64218197	rs114893434	S>I	H:242	(58.69, 37.83, 14.77)
15:64218194		Q>R	H:243	(58.30, 40.71, 12.33)
15:64218191		T>M	H:244	(63.58, 40.37, 12.95)
15:64218186		E>K	H:246	(68.26, 35.55, 10.83)
15:64218177		K>E	H:249	(68.85, 37.91, 14.79)
15:64218172		D>E	H:250	(74.78, 38.02, 13.03)
15:64218164	COSM1374013	R>Q	H:253	(74.22, 36.70, 17.55)
15:64218155		L>P	H:256	(76.60, 41.29, 22.37)
15:64218147		E>K	H:259	(86.46, 37.36, 24.30)
15:64218140		R>Q	H:261	(91.59, 38.73, 21.65)
15:64218141	rs34270163	R>W	H:261	(91.59, 38.73, 21.65)
15:64217058		K>R	H:262	(85.27, 36.66, 19.01)
15:64217055	rs145658373	R>Q	H:263	(83.61, 42.89, 21.72)
15:64217046	rs139000467	I>T	H:266	(83.79, 50.57, 14.03)
15:64217047	COSM3988051	I>V	H:266	(83.79, 50.57, 14.03)
15:64217035		L>F	H:270	(80.81, 50.02, 8.91)
15:64217029		H>Y	H:272	(77.71, 43.17, 9.08)
15:64217016		T>M	H:276	(77.26, 47.49, 4.02)
15:64215512		R>W	H:287	(62.96, 46.86, 0.79)
15:64215496	rs73450788	T>S	H:292	(58.02, 45.54, 17.25)
15:64215475		L>Q	H:299	(59.08, 49.16, 26.81)