Assessment of Structural Intolerance and Durability
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vyx DHX9 structural insights into risc assembly facilitated by dsrna binding domains of human rna helicase (dhx9) 2.29Å AUTH Q.FU,Y.A.YUANTITL STRUCTURAL INSIGHTS INTO RISC ASSEMBLY FACILITATED BYTITL 2 DSRNA-BINDING DOMAINS OF HUMAN RNA HELICASE A (DHX9)REF NUCLEIC ACIDS RES. 2013REFN ESSN 1362-4962PMID 23361462DOI 10.1093/NAR/GKT042 Variant Set Distributions Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 4k2p TIAM1 the structure of a quintuple mutant of the tiam1 ph-cc-ex domain 1.98Å AUTH M.JOSHI,L.GAKHAR,E.J.FUENTESTITL HIGH-RESOLUTION STRUCTURE OF THE TIAM1 PHN-CC-EX DOMAIN.REF ACTA CRYSTALLOGR.,SECT.F V. 69 744 2013REFN ESSN 1744-3091PMID 23832200DOI 10.1107/S1744309113014206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oob CBLB crystal structure of the uba domain from cbl-b ubiquitin ligase in complex with ubiquitin 1.9Å AUTH P.PESCHARD,G.KOZLOV,T.LIN,I.A.MIRZA,A.M.BERGHUIS,AUTH 2 S.LIPKOWITZ,M.PARK,K.GEHRINGTITL STRUCTURAL BASIS FOR UBIQUITIN-MEDIATEDTITL 2 DIMERIZATION AND ACTIVATION OF THE UBIQUITINTITL 3 PROTEIN LIGASE CBL-B.REF MOL.CELL V. 27 474 2007REFN ISSN 1097-2765PMID 17679095DOI 10.1016/J.MOLCEL.2007.06.023 Variant Set Distributions Mapped Variants
General Structure Information 2bkd FMR1 structure of the n-terminal domain of fragile x mental retardation protein -1.0Å AUTH A.RAMOS,D.HOLLINGWORTH,S.ADINOLFI,M.CASTETS,AUTH 2 G.KELLY,T.A.FRENKIEL,B.BARDONI,A.PASTORETITL THE STRUCTURE OF THE N-TERMINAL DOMAIN OF THETITL 2 FRAGILE X MENTAL RETARDATION PROTEIN: A PLATFORMTITL 3 FOR PROTEIN-PROTEIN INTERACTION.REF STRUCTURE V. 14 21 2006REFN ISSN 0969-2126PMID 16407062DOI 10.1016/J.STR.2005.09.018 Variant Set Distributions Mapped Variants
General Structure Information 3sf4 GPSM2 crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn 2.6Å AUTH S.YUZAWA,S.KAMAKURA,Y.IWAKIRI,J.HAYASE,H.SUMIMOTOTITL STRUCTURAL BASIS FOR INTERACTION BETWEEN THE CONSERVED CELLTITL 2 POLARITY PROTEINS INSCUTEABLE AND LEU-GLY-ASNTITL 3 REPEAT-ENRICHED PROTEIN (LGN)REF PROC.NATL.ACAD.SCI.USA V. 108 19210 2011REFN ISSN 0027-8424PMID 22074847DOI 10.1073/PNAS.1110951108 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2fju PLCB2 activated rac1 bound to its effector phospholipase c beta 2 2.2Å AUTH M.R.JEZYK,J.T.SNYDER,S.GERSHBERG,D.K.WORTHYLAKE,AUTH 2 T.K.HARDEN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 BOUND TO ITS EFFECTORTITL 2 PHOSPHOLIPASE C-BETA2.REF NAT.STRUCT.MOL.BIOL. V. 13 1135 2006REFN ISSN 1545-9993PMID 17115053DOI 10.1038/NSMB1175 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants