Assessment of Structural Intolerance and Durability
General Structure Information 1f4r MPG crystal structure of the human aag dna repair glycosylase complexed with 1,n6-ethenoadenine-dna 2.4Å AUTH A.Y.LAU,M.D.WYATT,B.J.GLASSNER,L.D.SAMSON,AUTH 2 T.ELLENBERGERTITL MOLECULAR BASIS FOR DISCRIMINATING BETWEEN NORMALTITL 2 AND DAMAGED BASES BY THE HUMAN ALKYLADENINETITL 3 GLYCOSYLASE, AAG.REF PROC.NATL.ACAD.SCI.USA V. 97 13573 2000REFN ISSN 0027-8424PMID 11106395DOI 10.1073/PNAS.97.25.13573 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2prt WT1 structure of the wilms tumor suppressor protein zinc finger domain bound to dna 3.15Å AUTH R.STOLL,B.M.LEE,E.W.DEBLER,J.H.LAITY,I.A.WILSON,AUTH 2 H.J.DYSON,P.E.WRIGHTTITL STRUCTURE OF THE WILMS TUMOR SUPPRESSOR PROTEINTITL 2 ZINC FINGER DOMAIN BOUND TO DNAREF J.MOL.BIOL. V. 372 1227 2007REFN ISSN 0022-2836PMID 17716689DOI 10.1016/J.JMB.2007.07.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1c9b TBP crystal structure of a human tbp core domain-human tfiib core domain complex bound to an extended, modified adenoviral major late promoter (admlp) 2.65Å AUTH F.T.TSAI,P.B.SIGLERTITL STRUCTURAL BASIS OF PREINITIATION COMPLEX ASSEMBLYTITL 2 ON HUMAN POL II PROMOTERS.REF EMBO J. V. 19 25 2000REFN ISSN 0261-4189PMID 10619841DOI 10.1093/EMBOJ/19.1.25 Variant Set Distributions […]
General Structure Information 1cqt POU2F1 crystal structure of a ternary complex containing an oca-b peptide, the oct-1 pou domain, and an octamer element 3.2Å AUTH D.CHASMAN,K.CEPEK,P.A.SHARP,C.O.PABOTITL CRYSTAL STRUCTURE OF AN OCA-B PEPTIDE BOUND TO ANTITL 2 OCT-1 POU DOMAIN/OCTAMER DNA COMPLEX: SPECIFICTITL 3 RECOGNITION OF A PROTEIN-DNA INTERFACE.REF GENES DEV. V. 13 2650 1999REFN ISSN […]
General Structure Information 1x9n LIG1 crystal structure of human dna ligase i bound to 5-adenylated, nicked dna 3.0Å AUTH J.M.PASCAL,P.J.OBRIEN,A.E.TOMKINSON,T.ELLENBERGERTITL HUMAN DNA LIGASE I COMPLETELY ENCIRCLES AND PARTIALLYTITL 2 UNWINDS NICKED DNA.REF NATURE V. 432 473 2004REFN ISSN 0028-0836PMID 15565146DOI 10.1038/NATURE03082 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1pgz HNRNPA1 crystal structure of up1 complexed with d(ttagggttag(6-mi) g); a human telomeric repeat containing 6-methyl-8-(2- deoxy-beta-ribofuranosyl)isoxanthopteridine (6-mi) 2.6Å AUTH J.C.MYERS,S.A.MOORE,Y.SHAMOOTITL STRUCTURE-BASED INCORPORATION OFTITL 2 6-METHYL-8-(2-DEOXY-BETA-RIBOFURANOSYL)TITL 3 ISOXANTHOPTERIDINE INTO THE HUMAN TELOMERIC REPEATTITL 4 DNA AS A PROBE FOR UP1 BINDING AND DESTABILIZATIONTITL 5 OF G-TETRAD STRUCTURESREF J.BIOL.CHEM. V. 278 42300 2003REFN […]
General Structure Information 4fm9 TOP2A human topoisomerase ii alpha bound to dna 2.9Å AUTH T.J.WENDORFF,B.H.SCHMIDT,P.HESLOP,C.A.AUSTIN,J.M.BERGERTITL THE STRUCTURE OF DNA-BOUND HUMAN TOPOISOMERASE II ALPHA:TITL 2 CONFORMATIONAL MECHANISMS FOR COORDINATING INTER-SUBUNITTITL 3 INTERACTIONS WITH DNA CLEAVAGE.REF J.MOL.BIOL. V. 424 109 2012REFN ISSN 0022-2836PMID 22841979DOI 10.1016/J.JMB.2012.07.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1kb4 VDR crystal structure of vdr dna-binding domain bound to a canonical direct repeat with three base pair spacer (dr3) response element 2.8Å AUTH P.L.SHAFFER,D.T.GEWIRTHTITL STRUCTURAL BASIS OF VDR-DNA INTERACTIONS ON DIRECTTITL 2 REPEAT RESPONSE ELEMENTS.REF EMBO J. V. 21 2242 2002REFN ISSN 0261-4189PMID 11980721DOI 10.1093/EMBOJ/21.9.2242 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 1hlv CENPB crystal structure of cenp-b(1-129) complexed with the cenp- b box dna 2.5Å AUTH Y.TANAKA,O.NUREKI,H.KURUMIZAKA,S.FUKAI,S.KAWAGUCHI,AUTH 2 M.IKUTA,J.IWAHARA,T.OKAZAKI,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE CENP-B PROTEIN-DNATITL 2 COMPLEX: THE DNA-BINDING DOMAINS OF CENP-B INDUCETITL 3 KINKS IN THE CENP-B BOX DNA.REF EMBO J. V. 20 6612 2001REFN ISSN 0261-4189PMID 11726497DOI 10.1093/EMBOJ/20.23.6612 Variant Set Distributions […]
General Structure Information 3w97 HIST1H2AE crystal structure of human nucleosome core particle lacking h2b n- terminal region 3.2Å AUTH W.IWASAKI,Y.MIYA,N.HORIKOSHI,A.OSAKABE,H.TAGUCHI,AUTH 2 H.TACHIWANA,T.SHIBATA,W.KAGAWA,H.KURUMIZAKATITL CONTRIBUTION OF HISTONE N-TERMINAL TAILS TO THE STRUCTURETITL 2 AND STABILITY OF NUCLEOSOMESREF FEBS OPEN BIO V. 3 363 2013REFN ESSN 2211-5463PMID 24251097DOI 10.1016/J.FOB.2013.08.007 Variant Set Distributions Mapped Variants