Assessment of Structural Intolerance and Durability
General Structure Information 1hcq ESR1 the crystal structure of the estrogen receptor dna-binding domain bound to dna: how receptors discriminate between their response elements 2.4Å AUTH J.W.SCHWABE,L.CHAPMAN,J.T.FINCH,D.RHODESTITL THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTORTITL 2 DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORSTITL 3 DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS.REF CELL(CAMBRIDGE,MASS.) V. 75 567 1993REFN ISSN 0092-8674PMID […]
General Structure Information 4mzr TP53 crystal structure of a polypeptide p53 mutant bound to dna 2.9Å AUTH S.EMAMZADAH,L.TROPIA,I.VINCENTI,B.FALQUET,T.D.HALAZONETISTITL REVERSAL OF THE DNA-BINDING-INDUCED LOOP L1 CONFORMATIONALTITL 2 SWITCH IN AN ENGINEERED HUMAN P53 PROTEIN.REF J.MOL.BIOL. V. 426 936 2014REFN ISSN 0022-2836PMID 24374182DOI 10.1016/J.JMB.2013.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1yo5 SPDEF analysis of the 2.0a crystal structure of the protein-dna complex of human pdef ets domain bound to the prostate specific antigen regulatory site 2.0Å AUTH Y.WANG,L.FENG,M.SAID,S.BALDERMAN,Z.FAYAZI,Y.LIU,AUTH 2 D.GHOSH,A.M.GULICKTITL ANALYSIS OF THE 2.0 A CRYSTAL STRUCTURE OF THETITL 2 PROTEIN-DNA COMPLEX OF THE HUMAN PDEF ETS DOMAINTITL 3 BOUND TO THE […]
General Structure Information 1imh NFAT5 tonebp/dna complex 2.86Å AUTH J.C.STROUD,C.LOPEZ-RODRIGUEZ,A.RAO,L.CHENTITL STRUCTURE OF A TONEBP-DNA COMPLEX REVEALS DNATITL 2 ENCIRCLED BY A TRANSCRIPTION FACTOR.REF NAT.STRUCT.BIOL. V. 9 90 2002REFN ISSN 1072-8368PMID 11780147DOI 10.1038/NSB749 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a66 NR5A2 human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter 2.2Å AUTH I.H.SOLOMON,J.M.HAGER,R.SAFI,D.P.MCDONNELL,AUTH 2 M.R.REDINBO,E.A.ORTLUNDTITL CRYSTAL STRUCTURE OF THE HUMAN LRH-1 DBD-DNATITL 2 COMPLEX REVEALS FTZ-F1 DOMAIN POSITIONING ISTITL 3 REQUIRED FOR RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 354 1091 2005REFN ISSN 0022-2836PMID 16289203DOI 10.1016/J.JMB.2005.10.009 Variant […]