Assessment of Structural Intolerance and Durability
General Structure Information 1m6d CTSF crystal structure of human cathepsin f 1.7Å AUTH J.R.SOMOZA,J.T.PALMER,J.D.HOTITL THE CRYSTAL STRUCTURE OF HUMAN CATHEPSIN F AND ITSTITL 2 IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL IMMUNOMODULATORSREF J.MOL.BIOL. V. 322 559 2002REFN ISSN 0022-2836PMID 12225749DOI 10.1016/S0022-2836(02)00780-5 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1deu CTSZ crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine 1.7Å AUTH J.SIVARAMAN,D.K.NAGLER,R.ZHANG,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINETITL 2 PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVETITL 3 SITE CYSTEINE.REF J.MOL.BIOL. V. 295 939 2000REFN ISSN 0022-2836PMID […]
General Structure Information 3i3t USP21 crystal structure of covalent ubiquitin-usp21 complex 2.59Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1uuc SPINK5 solution structure of a chimeric lekti-domain -1.0Å AUTH H.TIDOW,T.LAUBER,K.VITZITHUM,C.SOMMERHOFF,P.ROESCH,AUTH 2 U.C.MARXTITL THE SOLUTION STRUCTURE OF A CHIMERIC LEKTI DOMAINTITL 2 REVEALS A CHAMELEON SEQUENCEREF BIOCHEMISTRY V. 43 11238 2004REFN ISSN 0006-2960PMID 15366933DOI 10.1021/BI0492399 Variant Set Distributions Mapped Variants
General Structure Information 3ceg BIRC6 crystal structure of the ubc domain of baculoviral iap repeat- containing protein 6 2.01Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ctz XPNPEP1 structure of human cytosolic x-prolyl aminopeptidase 1.6Å AUTH X.LI,Z.LOU,X.LI,W.ZHOU,M.MA,Y.CAO,Y.GENG,M.BARTLAM,AUTH 2 X.C.ZHANG,Z.RAOTITL STRUCTURE OF HUMAN CYTOSOLIC X-PROLYL AMINOPEPTIDASE: ATITL 2 DOUBLE MN(II)-DEPENDENT DIMERIC ENZYME WITH A NOVELTITL 3 THREE-DOMAIN SUBUNITREF J.BIOL.CHEM. V. 283 22858 2008REFN ISSN 0021-9258PMID 18515364DOI 10.1074/JBC.M710274200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1uvg SPINK5 solution structure of the 15th domain of lekti -1.0Å AUTH H.TIDOW,T.LAUBER,K.VITZITHUM,C.SOMMERHOFF,P.ROESCH,AUTH 2 U.C.MARXTITL THE SOLUTION STRUCTURE OF A CHIMERIC LEKTI DOMAINTITL 2 REVEALS A CHAMELEON SEQUENCEREF BIOCHEMISTRY V. 43 11238 2004REFN ISSN 0006-2960PMID 15366933DOI 10.1021/BI0492399 Variant Set Distributions Mapped Variants
General Structure Information 2gwf RNF41 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]