Assessment of Structural Intolerance and Durability
General Structure Information 3ikk VAPB crystal structure analysis of msp domain 2.5Å AUTH J.SHI,S.LUA,J.S.TONG,J.SONGTITL ELIMINATION OF THE NATIVE STRUCTURE AND SOLUBILITY OF THETITL 2 HVAPB MSP DOMAIN BY THE PRO56SER MUTATION THAT CAUSESTITL 3 AMYOTROPHIC LATERAL SCLEROSIS.REF BIOCHEMISTRY V. 49 3887 2010REFN ISSN 0006-2960PMID 20377183DOI 10.1021/BI902057A Variant Set Distributions Mapped Variants
General Structure Information 3ggr RAD1 crystal structure of the human rad9-hus1-rad1 complex 3.2Å AUTH M.XU,L.BAI,Y.GONG,W.XIE,H.Y.HANG,T.JIANGTITL STRUCTURE AND FUNCTIONAL IMPLICATIONS OF THE HUMANTITL 2 RAD9-HUS1-RAD1 CELL CYCLE CHECKPOINT COMPLEXREF J.BIOL.CHEM. V. 284 20457 2009REFN ISSN 0021-9258PMID 19535328DOI 10.1074/JBC.C109.022384 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3eh1 SEC24B crystal structure of the human copii-coat protein sec24b 1.8Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEINTITL 2 DISCRIMINATION BY THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k6m SVIL solution structure of human supervillin headpiece -1.0Å AUTH J.W.BROWN,D.VARDAR-ULU,C.J.MCKNIGHTTITL HOW TO ARM A SUPERVILLIN: DESIGNING F-ACTIN BINDINGTITL 2 ACTIVITY INTO SUPERVILLIN HEADPIECE.REF J.MOL.BIOL. V. 393 608 2009REFN ISSN 0022-2836PMID 19683541DOI 10.1016/J.JMB.2009.08.018 Variant Set Distributions Mapped Variants
General Structure Information 3bh7 RP2 crystal structure of the rp2-arl3 complex bound to gdp-alf4 1.9Å AUTH S.VELTEL,R.GASPER,E.EISENACHER,A.WITTINGHOFERTITL THE RETINITIS PIGMENTOSA 2 GENE PRODUCT IS ATITL 2 GTPASE-ACTIVATING PROTEIN FOR ARF-LIKE 3REF NAT.STRUCT.MOL.BIOL. V. 15 373 2008REFN ISSN 1545-9993PMID 18376416DOI 10.1038/NSMB.1396 Variant Set Distributions Mapped Variants
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bpj EIF3J crystal structure of human translation initiation factor 3, subunit 1 alpha 1.85Å AUTH L.NEDYALKOVA,B.HONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN TRANSLATION INITIATION FACTOR 3,TITL 2 SUBUNIT 1 ALPHA.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3g65 HUS1 crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3l6y CTNND1 crystal structure of p120 catenin in complex with e-cadherin 3.0Å AUTH N.ISHIYAMA,S.H.LEE,S.LIU,G.Y.LI,M.J.SMITH,L.F.REICHARDT,AUTH 2 M.IKURATITL DYNAMIC AND STATIC INTERACTIONS BETWEEN P120 CATENIN ANDTITL 2 E-CADHERIN REGULATE THE STABILITY OF CELL-CELL ADHESION.REF CELL(CAMBRIDGE,MASS.) V. 141 117 2010REFN ISSN 0092-8674PMID 20371349DOI 10.1016/J.CELL.2010.01.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3k27 EED complex structure of eed and trimethylated h3k9 1.76Å AUTH C.XU,C.BIAN,W.YANG,M.GALKA,H.OUYANG,C.CHEN,W.QIU,H.LIU,AUTH 2 A.E.JONES,F.MACKENZIE,P.PAN,S.S.LI,H.WANG,J.MINTITL BINDING OF DIFFERENT HISTONE MARKS DIFFERENTIALLY REGULATESTITL 2 THE ACTIVITY AND SPECIFICITY OF POLYCOMB REPRESSIVE COMPLEXTITL 3 2 (PRC2).REF PROC.NATL.ACAD.SCI.USA V. 107 19266 2010REFN ISSN 0027-8424PMID 20974918DOI 10.1073/PNAS.1008937107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]