Assessment of Structural Intolerance and Durability
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2bzl PTPN14 crystal structure of the human protein tyrosine phosphatase n14 at 1.65 a resolution 1.65Å AUTH A.J.BARR,J.E.DEBRECZENI,J.ESWARAN,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE 14 (PTPN14) AT 1.65-A RESOLUTION.REF PROTEINS V. 63 1132 2006REFN ISSN 0887-3585PMID 16534812DOI 10.1002/PROT.20958 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2hv7 PPP2R4 crystal structure of phosphotyrosyl phosphatase activator bound to atpgammas 2.5Å AUTH Y.CHAO,Y.XING,Y.CHEN,Y.XU,Z.LIN,Z.LI,P.D.JEFFREY,AUTH 2 J.B.STOCK,Y.SHITITL STRUCTURE AND MECHANISM OF THE PHOSPHOTYROSYLTITL 2 PHOSPHATASE ACTIVATOR.REF MOL.CELL V. 23 535 2006REFN ISSN 1097-2765PMID 16916641DOI 10.1016/J.MOLCEL.2006.07.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c7s PTPRK crystal structure of human protein tyrosine phosphatase kappa at 1.95a resolution 1.95Å AUTH J.ESWARAN,J.E.DEBRECZENI,E.LONGMAN,A.BARR,S.KNAPPTITL THE CRYSTAL STRUCTURE OF HUMAN RECEPTOR PROTEIN TYROSINETITL 2 KAPPA PHOSPHATASE KAPPA DOMAIN 1.REF PROTEIN SCI. V. 15 1500 2006REFN ISSN 0961-8368PMID 16672235DOI 10.1110/PS.062128706 Variant Set Distributions Mapped Variants
General Structure Information 1m3g DUSP2 solution structure of the catalytic domain of mapk phosphatase pac-1: insights into substrate-induced enzymatic activation -1.0Å AUTH A.FAROOQ,O.PLOTNIKOVA,G.CHATURVEDI,S.YAN,L.ZENG,AUTH 2 Q.ZHANG,M.-M.ZHOUTITL SOLUTION STRUCTURE OF THE MAPK PHOSPHATASE PAC-1TITL 2 CATALYTIC DOMAIN INSIGHTS INTO SUBSTRATE-INDUCEDTITL 3 ENZYMATIC ACTIVATION OF MKPREF STRUCTURE V. 11 155 2003REFN ISSN 0969-2126PMID 12575935DOI 10.1016/S0969-2126(02)00943-7 Variant Set Distributions […]
General Structure Information 4i5k PPP2R3A pp2a pr70 holoenzyme model3_dica_rcsb.pdb bppnat5_extend.mtz 2.9Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants