Assessment of Structural Intolerance and Durability
General Structure Information 4i5l PPP2R3B structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation 2.43Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 3c5w PPME1 complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme 2.8Å AUTH Y.XING,Z.LI,Y.CHEN,J.B.STOCK,P.D.JEFFREY,Y.SHITITL STRUCTURAL MECHANISM OF DEMETHYLATION AND INACTIVATION OFTITL 2 PROTEIN PHOSPHATASE 2A.REF CELL(CAMBRIDGE,MASS.) V. 133 154 2008REFN ISSN 0092-8674PMID 18394995DOI 10.1016/J.CELL.2008.02.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wrm DUSP22 crystal structure of jsp-1 1.5Å AUTH T.YOKOTA,Y.NARA,A.KASHIMA,K.MATSUBARA,S.MISAWA,AUTH 2 R.KATO,S.SUGIOTITL CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITYTITL 2 PHOSPHATASE, JNK STIMULATORY PHOSPHATASE-1, AT 1.5TITL 3 A RESOLUTIONREF PROTEINS V. 66 272 2006REFN ISSN 0887-3585PMID 17068812DOI 10.1002/PROT.21152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4h3k SSU72 crystal structure of a ternary complex of human symplekin ntd, human ssu72 and a rna polymerase ii ctd peptide phosphorylated at ser-2, ser-5 and ser-7 2.0Å AUTH K.XIANG,J.L.MANLEY,L.TONGTITL AN UNEXPECTED BINDING MODE FOR A POL II CTD PEPTIDETITL 2 PHOSPHORYLATED AT SER7 IN THE ACTIVE SITE OF THE CTDTITL 3 […]
General Structure Information 3lj8 DUSP9 crystal structure of mkp-4 2.7Å AUTH D.G.JEONG,T.S.YOON,S.-K.JUNG,B.C.PARK,H.S.PARK,S.E.RYU,AUTH 2 S.J.KIMTITL EXPLORING BINDING SITES OTHER THAN THE CATALYTIC CORE IN THETITL 2 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MKP-4REF ACTA CRYSTALLOGR.,SECT.D V. 67 25 2011REFN ISSN 0907-4449PMID 21206059DOI 10.1107/S0907444910042381 Variant Set Distributions Mapped Variants
General Structure Information 3l0c CTDSP1 crystal structure of scp1 phosphatase d206a mutant with trapped inorganic phosphate 2.45Å AUTH M.ZHANG,J.LIU,Y.KIM,J.E.DIXON,S.L.PFAFF,G.N.GILL,J.P.NOEL,AUTH 2 Y.ZHANGTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PHOSPHORYLTITL 2 TRANSFER REACTION MEDIATED BY THE HUMAN SMALL C-TERMINALTITL 3 DOMAIN PHOSPHATASE, SCP1.REF PROTEIN SCI. V. 19 974 2010REFN ISSN 0961-8368PMID 20222012DOI 10.1002/PRO.375 Variant Set Distributions Mapped […]
General Structure Information 3tg3 DUSP16 crystal structure of the mapk binding domain of mkp7 2.67Å AUTH Y.Y.ZHANG,J.W.WU,Z.X.WANGTITL A DISTINCT INTERACTION MODE REVEALED BY THE CRYSTALTITL 2 STRUCTURE OF THE KINASE P38ALPHA WITH THE MAPK BINDINGTITL 3 DOMAIN OF THE PHOSPHATASE MKP5.REF SCI.SIGNAL. V. 4 RA88 2011REFN ESSN 1937-9145PMID 22375048DOI 10.1126/SCISIGNAL.2002241 Variant Set Distributions Mapped Variants
General Structure Information 4gfv PTPN18 ptpn18 in complex with her2-py1196 phosphor-peptides 2.1Å AUTH H.M.WANG,F.YANG,Y.J.DU,D.X.YANG,Y.ZHANG,X.YU,J.P.SUNTITL PTPN18-HER2 PEPTIDESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o2q SYMPK crystal structure of the human symplekin-ssu72-ctd phosphopeptide complex 2.4Å AUTH K.XIANG,T.NAGAIKE,S.XIANG,T.KILIC,M.M.BEH,J.L.MANLEY,L.TONGTITL CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72-CTDTITL 2 PHOSPHOPEPTIDE COMPLEX.REF NATURE V. 467 729 2010REFN ISSN 0028-0836PMID 20861839DOI 10.1038/NATURE09391 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2m17 UBLCP1 ubiquitin-like domain-containing c-terminal domain phosphatase (ublcp1) -1.0Å AUTH J.H.YUN,S.KO,C.K.LEE,H.K.CHEONG,C.CHEONG,J.B.YOON,W.LEETITL SOLUTION STRUCTURE AND RPN1 INTERACTION OF THE UBL DOMAIN OFTITL 2 HUMAN RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE.REF PLOS ONE V. 8 62981 2013REFN ESSN 1932-6203PMID 23667555DOI 10.1371/JOURNAL.PONE.0062981 Variant Set Distributions Mapped Variants