Assessment of Structural Intolerance and Durability
General Structure Information 4hon KDM4D crystal structure of human jmjd2d/kdm4d in complex with an h3k9me3 peptide and 2-oxoglutarate 1.8Å AUTH S.KRISHNAN,R.C.TRIEVELTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF JMJD2D REVEALSTITL 2 MOLECULAR BASIS FOR SITE-SPECIFIC DEMETHYLATION AMONG JMJD2TITL 3 DEMETHYLASES.REF STRUCTURE V. 21 98 2013REFN ISSN 0969-2126PMID 23219879DOI 10.1016/J.STR.2012.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2y73 AOC3 the native structures of soluble human primary amine oxidase aoc3 2.6Å AUTH H.ELOVAARA,H.KIDRON,V.PARKASH,Y.NYMALM,E.BLIGT,P.OLLIKKA,AUTH 2 D.J.SMITH,M.PIHLAVISTO,M.SALMI,S.JALKANEN,T.A.SALMINENTITL IDENTIFICATION OF TWO IMIDAZOLE BINDING SITES AND KEYTITL 2 RESIDUES FOR SUBSTRATE SPECIFICITY IN HUMAN PRIMARY AMINETITL 3 OXIDASE AOC3.REF BIOCHEMISTRY V. 50 5507 2011REFN ISSN 0006-2960PMID 21585208DOI 10.1021/BI200117Z Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3she MAPKAPK3 novel atp-competitive mk2 inhibitors with potent biochemical and cell- based activity throughout the series 2.25Å AUTH A.OUBRIE,A.KAPTEIN,E.DE ZWART,N.HOOGENBOOM,R.GOORDEN,AUTH 2 B.VAN DE KAR,M.VAN HOEK,V.DE KIMPE,R.VAN DER HEIJDEN,AUTH 3 J.BORSBOOM,B.KAZEMIER,J.DE ROOS,M.SCHEFFERS,J.LOMMERSE,AUTH 4 C.SCHULTZ-FADEMRECHT,T.BARFTITL NOVEL ATP COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICALTITL 2 AND CELL-BASED ACTIVITY THROUGHOUT THE SERIES.REF BIOORG.MED.CHEM.LETT. V. 22 613 […]
General Structure Information 4kit PRPF8 crystal structure of human brr2 in complex with the prp8 jab1/mpn domain 3.6Å AUTH S.MOZAFFARI-JOVIN,T.WANDERSLEBEN,K.F.SANTOS,C.L.WILL,AUTH 2 R.LUHRMANN,M.C.WAHLTITL INHIBITION OF RNA HELICASE BRR2 BY THE C-TERMINAL TAIL OFTITL 2 THE SPLICEOSOMAL PROTEIN PRP8.REF SCIENCE V. 341 80 2013REFN ISSN 0036-8075PMID 23704370DOI 10.1126/SCIENCE.1237515 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d8b FIGNL1 crystal structure of human fidgetin-like protein 1 in complex with adp 2.0Å AUTH T.KARLBERG,M.WISNIEWSKA,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,AUTH 5 M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,M.WELIN,AUTH 7 M.WIKSTROM,H.SCHULERTITL HUMAN FIDGETIN-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]
General Structure Information 3a6n HIST3H3 the nucleosome containing a testis-specific histone variant, human h3t 2.7Å AUTH H.TACHIWANA,W.KAGAWA,A.OSAKABE,K.KAWAGUCHI,T.SHIGA,AUTH 2 Y.HAYASHI-TAKANAKA,H.KIMURA,H.KURUMIZAKATITL STRUCTURAL BASIS OF INSTABILITY OF THE NUCLEOSOME CONTAININGTITL 2 A TESTIS-SPECIFIC HISTONE VARIANT, HUMAN H3TREF PROC.NATL.ACAD.SCI.USA V. 107 10454 2010REFN ISSN 0027-8424PMID 20498094DOI 10.1073/PNAS.1003064107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1wwc NTRK3 nt3 binding domain of human trkc receptor 1.9Å AUTH M.H.ULTSCH,C.WIESMANN,L.C.SIMMONS,J.HENRICH,M.YANG,D.REILLY,AUTH 2 S.H.BASS,A.M.DE VOSTITL CRYSTAL STRUCTURES OF THE NEUROTROPHIN-BINDING DOMAIN OFTITL 2 TRKA, TRKB AND TRKC.REF J.MOL.BIOL. V. 290 149 1999REFN ISSN 0022-2836PMID 10388563DOI 10.1006/JMBI.1999.2816 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ocp DGUOK crystal structure of human deoxyguanosine kinase 2.8Å AUTH K.JOHANSSON,S.RAMASWAMY,C.LJUNGKRANTZ,W.KNECHT,AUTH 2 J.PISKUR,B.MUNCH-PETERSEN,S.ERIKSSON,H.EKLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITIES OFTITL 2 CELLULAR DEOXYRIBONUCLEOSIDE KINASES.REF NAT.STRUCT.BIOL. V. 8 616 2001REFN ISSN 1072-8368PMID 11427893DOI 10.1038/89661 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yrv UBE2U novel ubiquitin-conjugating enzyme 2.18Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants